PMID- 19551681
OWN - NLM
STAT- MEDLINE
DCOM- 20091124
LR  - 20190917
IS  - 1120-6721 (Print)
IS  - 1120-6721 (Linking)
VI  - 19
IP  - 4
DP  - 2009 Jul-Aug
TI  - HLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes 
      mellitus.
PG  - 638-45
AB  - PURPOSE: To investigate if diabetic patients without diabetic retinopathy despite 
      long disease duration have different human leukocyte antigen (HLA) status vs 
      those with an early onset of retinopathy. METHODS: Retrospective, nonrandomized, 
      masked comparative study. Type 1 diabetic patients with a disease onset before 
      age 30 were recruited to the study. The study population consisted of two groups 
      of diabetic patients: those with normal retinopathy course (retinopathy developed 
      during the first 20 years of diabetes onset) (23 patients) and those with 
      postponed retinopathy (no obvious retinopathy in spite of passing 20 years of 
      diabetes) (19 patients). These groups were matched with regard to level of 
      glycemic control, blood pressure, and lipid profile. A group of 23 healthy 
      patients served as controls. HLA-DQB1 typing of blood samples was done using a 
      polymerase chain reaction with sequence-specific primer (PCR-SSP) method. 
      RESULTS: HLA-DQB1*0201/HLA-DQB1*0501 and HLA-DQB1*0201/HLA-DQB1*0504 haplotypes 
      were more common among type 1 diabetic patients with normal retinopathy course 
      than those with postponed retinopathy (26.1% vs 0.0%; p=0.019). HLA-DQB1*0301 and 
      HLA-DQB1*0304 were less common among those diabetic patients with normal 
      retinopathy course than those with a postponed retinopathy (63.2% vs 34.8%; 
      p=0.067). CONCLUSIONS: Some haplotypes seem to predispose diabetic patients to 
      diabetic retinopathy. HLA typing may be beneficial for predicting the prognosis 
      of diabetic retinopathy in younger diabetic patients.
FAU - Khazaee, Mohammad H
AU  - Khazaee MH
AD  - Internal Medicine Department, Emam Reza General Hospital, Mashhad University of 
      Medical Sciences, Mashhad - Iran.
FAU - Tavakol Afshari, Jalil
AU  - Tavakol Afshari J
FAU - Khazaee, Bahram
AU  - Khazaee B
FAU - Daneshvar, Ramin
AU  - Daneshvar R
FAU - Akbarzadeh, Javad
AU  - Akbarzadeh J
FAU - Khazaee, Ladan
AU  - Khazaee L
FAU - Ganjali, Rashin
AU  - Ganjali R
FAU - Raygan, Firoozeh
AU  - Raygan F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
RN  - 0 (Blood Glucose)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Blood Pressure
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Diabetic Retinopathy/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Polymerase Chain Reaction
MH  - Retrospective Studies
EDAT- 2009/06/25 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/06/25 09:00
PHST- 2009/06/25 09:00 [entrez]
PHST- 2009/06/25 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - 10.1177/112067210901900419 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2009 Jul-Aug;19(4):638-45. doi: 10.1177/112067210901900419.