PMID- 19551762
OWN - NLM
STAT- MEDLINE
DCOM- 20091020
LR  - 20220321
IS  - 1099-1077 (Electronic)
IS  - 0885-6222 (Linking)
VI  - 24
IP  - 6
DP  - 2009 Aug
TI  - A safety and tolerability laboratory study of the combination of aripiprazole and 
      topiramate in volunteers who drink alcohol.
PG  - 465-72
LID - 10.1002/hup.1042 [doi]
AB  - OBJECTIVE: There are no reports examining the safety of taking both topiramate 
      and aripiprazole together with alcohol. The ultimate aim for this research is to 
      determine whether this combination is safe and is superior to either drug taken 
      alone in reducing alcohol use in alcohol dependent patients. METHOD: This was an 
      open-label trial. Thirteen heavy drinking participants not seeking treatment for 
      alcoholism were randomized. Participants were titrated up to 300 mg of topiramate 
      and 30 mg of aripiprazole a day over 35 days. Participants reported adverse 
      events (AEs) daily alcohol use and participated in an alcohol challenge session 
      (ACS). RESULTS: The eight participants who completed the study achieved the 
      maximum doses of drugs. The AEs of the drugs would suggest that the AEs profile 
      is broader but not additive. Alcohol use from the 28 days before screening to the 
      seven days before the ACS was reduced (p = 0.08). CONCLUSION: There was no 
      evidence that AEs of aripiprazole and topiramate are additive and can, therefore, 
      be administered safely together with a modest amount of alcohol. There was also a 
      trend for a reduction of alcohol use by participants. This finding has 
      implications for further investigation of this combination of drugs for alcohol 
      dependence.
CI  - 2009 John Wiley & Sons, Ltd.
FAU - Kenna, George A
AU  - Kenna GA
AD  - Department of Psychiatry and the Center for Alcohol and Addiction Studies, Brown 
      University, Providence, Rhode Island, USA. George_Kenna@Brown.edu
FAU - Leggio, Lorenzo
AU  - Leggio L
FAU - Swift, Robert M
AU  - Swift RM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Hum Psychopharmacol
JT  - Human psychopharmacology
JID - 8702539
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Piperazines)
RN  - 0 (Quinolones)
RN  - 0H73WJJ391 (Topiramate)
RN  - 30237-26-4 (Fructose)
RN  - 82VFR53I78 (Aripiprazole)
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/*adverse effects
MH  - Alcoholism/rehabilitation
MH  - Antipsychotic Agents/administration & dosage/*adverse effects
MH  - Aripiprazole
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Female
MH  - Fructose/administration & dosage/adverse effects/*analogs & derivatives
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuroprotective Agents/administration & dosage/adverse effects
MH  - Piperazines/administration & dosage/*adverse effects
MH  - Quinolones/administration & dosage/*adverse effects
MH  - Topiramate
MH  - Young Adult
EDAT- 2009/06/25 09:00
MHDA- 2009/10/21 06:00
CRDT- 2009/06/25 09:00
PHST- 2009/06/25 09:00 [entrez]
PHST- 2009/06/25 09:00 [pubmed]
PHST- 2009/10/21 06:00 [medline]
AID - 10.1002/hup.1042 [doi]
PST - ppublish
SO  - Hum Psychopharmacol. 2009 Aug;24(6):465-72. doi: 10.1002/hup.1042.