PMID- 19552501
OWN - NLM
STAT- MEDLINE
DCOM- 20091208
LR  - 20090924
IS  - 1551-3793 (Electronic)
IS  - 1551-3777 (Linking)
VI  - 5
IP  - 4
DP  - 2009 Oct
TI  - Use of (eco)toxicity data as screening criteria for the identification and 
      classification of PBT/POP compounds.
PG  - 680-96
LID - 10.1897/IEAM_2009-013.1 [doi]
AB  - Characterization of "significant adverse ecotoxicological effects" of persistent 
      organic pollutants (POPs) presents particular challenges. In the various 
      international conventions on POPs and persistent, bioaccumulative, and toxic 
      substances, guidance on classification is not detailed and, in some cases, is 
      unclear. This paper focuses on several key issues in relation to selection of 
      assessment endpoints, use of appropriate effect measures, and uncertainty in the 
      face of limited data. Because POPs are persistent and bioaccumulative, measures 
      of effect should be based not on concentrations in environmental matrices but 
      rather on residues in the body of the organism or in tissues that are causally 
      linked to adverse responses. To obtain these data, currently used toxicity 
      testing methods may need to be modified or substantiated by toxicokinetic 
      information to ensure that substances with POP-like properties are adequately 
      characterized. These data can be more easily matched to environmental monitoring 
      measurements of body or tissue residues for the purposes of assessing whether 
      adverse effects occur in the environment. In the face of persistence and 
      accumulation in the food chain, and considering the extent and suitability of 
      available data, a suitable policy on the use of uncertainty factors may need to 
      be applied when making judgments about toxicity. This paper offers guidance that 
      can be used to identify candidate POPs that have the potential to cause 
      significant adverse effects in the ecosystem.
FAU - Solomon, Keith R
AU  - Solomon KR
AD  - University of Guelph, Centre for Toxicology, Guelph, Ontario N1G2W1, Canada. 
      ksolomon@uoguelph.ca
FAU - Dohmen, Peter
AU  - Dohmen P
FAU - Fairbrother, Anne
AU  - Fairbrother A
FAU - Marchand, Marcelle
AU  - Marchand M
FAU - McCarty, Lynn
AU  - McCarty L
LA  - eng
PT  - Journal Article
DEP - 20090624
PL  - United States
TA  - Integr Environ Assess Manag
JT  - Integrated environmental assessment and management
JID - 101234521
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hazardous Substances)
SB  - IM
MH  - Environmental Exposure/analysis
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/*analysis
MH  - Hazardous Substances/analysis
EDAT- 2009/06/26 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/06/26 09:00
PHST- 2009/01/25 00:00 [received]
PHST- 2009/06/17 00:00 [accepted]
PHST- 2009/06/26 09:00 [entrez]
PHST- 2009/06/26 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - IEAM_2009-013 [pii]
AID - 10.1897/IEAM_2009-013.1 [doi]
PST - ppublish
SO  - Integr Environ Assess Manag. 2009 Oct;5(4):680-96. doi: 10.1897/IEAM_2009-013.1. 
      Epub 2009 Jun 24.