PMID- 19552583
OWN - NLM
STAT- MEDLINE
DCOM- 20091230
LR  - 20131121
IS  - 1091-7691 (Electronic)
IS  - 0895-8378 (Linking)
VI  - 21
IP  - 12
DP  - 2009 Oct
TI  - Asian sand dust aggravates allergic rhinitis in guinea pigs induced by Japanese 
      cedar pollen.
PG  - 985-93
LID - 10.1080/08958370802672883 [doi]
AB  - Asian sand dust (ASD) contains microbial materials, sulfate (SO(4)(2-)), and 
      nitrate (NO(3)(-)), and is derived from air pollutants in East China. ASD 
      reportedly causes adverse respiratory health effects; a case in point is 
      aggravated allergen-associated experimental lung eosinophilia. Guinea pigs were 
      administered normal saline (control), ASD (0.3 mg/animal), ASD (0.6 mg/animal), 
      Japanese cedar pollen (JCP) (0.2 mg/kg body weight), JCP + ASD (0.3 mg/animal), 
      or JCP + ASD (0.6 mg/animal), into their nasal cavities at seven weekly 
      intervals. The number of sneezes, amount of nasal secretions, and nasal 
      obstructing response were measured as indices of nasal responses. Total 
      immunoglobulin E (IgE) antibodies in serum and the number of eosinophils, 
      histamine, and arachidonic acid metabolites in nasal cavity lavage fluids (NCLF) 
      were also measured. ASD enhanced the JCP-associated nasal obstructing response, 
      but not the number of sneezes or amount of nasal secretions. ASD enhanced 
      JCP-associated cysteinyl leukotrienes (C(4), D(4), E(4)) and histamine production 
      in NCLF. ASD augmented the number of eosinophils in NCLF and total IgE in serum 
      induced by JCP. ASD enhanced eosinophil recruitment in the nasal mucosa, and 
      goblet cell proliferation in the nasal epithelium induced by JCP. These results 
      suggest that ASD enhances the nasal allergic reaction induced by repeated JCP 
      administration in guinea pigs.
FAU - Ichinose, Takamichi
AU  - Ichinose T
AD  - Department of Health Sciences, Oita University of Nursing and Health Sciences, 
      Notsuharu, Oita, Japan.
FAU - Hiyoshi, Kyoko
AU  - Hiyoshi K
FAU - Yoshida, Seiichi
AU  - Yoshida S
FAU - Takano, Hirohisa
AU  - Takano H
FAU - Inoue, Kenichi
AU  - Inoue K
FAU - Nishikawa, Masataka
AU  - Nishikawa M
FAU - Mori, Ikuko
AU  - Mori I
FAU - Kawazato, Hiroaki
AU  - Kawazato H
FAU - Yasuda, Aiko
AU  - Yasuda A
FAU - Shibamoto, Takayuki
AU  - Shibamoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Dust)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Oxides)
RN  - 0 (Sulfates)
RN  - 0 (beta-Glucans)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Administration, Intranasal
MH  - Air Pollutants/*analysis/*toxicity
MH  - Animals
MH  - Arachidonic Acid/metabolism
MH  - Asia
MH  - Cell Count
MH  - *Cryptomeria
MH  - Dust/*analysis
MH  - Eosinophils/drug effects
MH  - Guinea Pigs
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/analysis/biosynthesis
MH  - Inhalation Exposure
MH  - Lipopolysaccharides/analysis/toxicity
MH  - Male
MH  - Nasal Cavity/pathology
MH  - Nasal Mucosa/pathology
MH  - Oxides/analysis/toxicity
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Perennial/immunology/*pathology
MH  - Silicon Dioxide/*analysis/*toxicity
MH  - Sulfates/analysis/toxicity
MH  - beta-Glucans/analysis/toxicity
EDAT- 2009/06/26 09:00
MHDA- 2009/12/31 06:00
CRDT- 2009/06/26 09:00
PHST- 2009/06/26 09:00 [entrez]
PHST- 2009/06/26 09:00 [pubmed]
PHST- 2009/12/31 06:00 [medline]
AID - 10.1080/08958370802672883 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2009 Oct;21(12):985-93. doi: 10.1080/08958370802672883.