PMID- 19552838
OWN - NLM
STAT- MEDLINE
DCOM- 20091006
LR  - 20210115
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 89
IP  - 4
DP  - 2009 Feb 3
TI  - [Relationship of serum Chemerin to obesity and type 2 diabetes mellitus].
PG  - 235-8
AB  - OBJECTIVE: To detect the serum Chemerin levels in patients with obesity and newly 
      diagnosed type 2 diabetes mellitus (T2DM) and explore the relationship of serum 
      Chemerin to body fat parameters, glucose and lipid metabolism, and insulin 
      resistance index (IR). METHODS: 76 newly diagnosed T2DM patients and 76 subjects 
      with normal glucose regulation (NGR), with the body mass index (BMI) < 25 kg/m(2) 
      (NW) or > or = 25 kg/m(2) (OW/OB), 38 in each subgroups each, underwent body 
      measurement including body weight, height, waist circumference, and hip 
      circumference, and waist hip ratio (WHR) and calculation of body mass index (BMI) 
      were calculated. Peripheral blood samples were collected from them to detect the 
      blood lipids, glucose, hemoglobin A1C, fasting insulin (FINS), and fasting C 
      peptide. Homeostasis model assessment insulin resistance index (HOMA-IR) was 
      calculated. ELISA was used to detect the Chemerin level, body mass index (BMI) 
      and waist hip ratio (WHR) were evaluated and insulin sensitivity was assessed by 
      HOMA-IR. RESULTS: The serum Chemerin level of the females was (109 +/- 28) 
      microg/L, significantly higher than that of the males [(98 +/- 23) microg/L, P < 
      0.05]. After adjustment of gender and age, the serum Chemerin level of the OW/OB 
      group, including NGR-OW/OB and T2DM-OW/OB subgroups, was (113 +/- 27) microg/L, 
      significantly higher than that of the NW group [(94 +/- 25) microg/L, P < 0.01], 
      that of the NGR-OW/OB subgroup being the highest. Partial correlation analyses 
      showed that the serum Chemerin was positively correlated with waist 
      circumference, WHR, fasting serum C peptide, HOMA-IR, TG, ALT, gamma-GT, and uric 
      acid (r = 0.460 - 0.182, all P < 0.05) and negatively correlated with high 
      density lipoprotein-cholesterol (r = -0.251, P < 0.01). Stepwise regression 
      analysis showed that fasting serum C peptide and TG were the independent 
      variables of Chemerin (beta = 0.328, 0.280, P < 0.05). CONCLUSION: Serum Chemerin 
      levels are much higher in females and obese subjects are much higher than in men 
      and subjects with normal weight. Serum Chemerin is correlated with insulin level, 
      body fat disposition and lipid metabolism which suggesting that it may play a 
      role in the pathophysiology of obesity and metabolic syndrome.
FAU - Wang, Ling-yan
AU  - Wang LY
AD  - Shanghai Clinical Center for Diabetes, Jiaotong University, Shanghai 200233, 
      China.
FAU - Wei, Li
AU  - Wei L
FAU - Yu, Hao-yong
AU  - Yu HY
FAU - Zhang, Yang
AU  - Zhang Y
FAU - Jia, Wei-ping
AU  - Jia WP
LA  - chi
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (Chemokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (RARRES2 protein, human)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Adult
MH  - Body Mass Index
MH  - Body Weight
MH  - Chemokines/*blood
MH  - Diabetes Mellitus, Type 2/*metabolism/physiopathology
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Intercellular Signaling Peptides and Proteins
MH  - Lipid Metabolism
MH  - Male
MH  - Middle Aged
MH  - Obesity/*metabolism/physiopathology
EDAT- 2009/06/26 09:00
MHDA- 2009/10/07 06:00
CRDT- 2009/06/26 09:00
PHST- 2009/06/26 09:00 [entrez]
PHST- 2009/06/26 09:00 [pubmed]
PHST- 2009/10/07 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2009 Feb 3;89(4):235-8.