PMID- 19555370
OWN - NLM
STAT- MEDLINE
DCOM- 20091026
LR  - 20211020
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 8
IP  - 4
DP  - 2009 Aug
TI  - Gene expression profiling of aging in multiple mouse strains: identification of 
      aging biomarkers and impact of dietary antioxidants.
PG  - 484-95
LID - 10.1111/j.1474-9726.2009.00496.x [doi]
AB  - We used DNA microarrays to identify panels of transcriptional markers of aging 
      that are differentially expressed in young (5 month) and old (25 month) mice of 
      multiple inbred strains (129sv, BALB/c, CBA, DBA, B6, C3H and B6C3F(1)). In the 
      heart, age-related changes of five genes were studied throughout the mouse 
      lifespan: complement component 4, chemokine ligand 14, component of Sp100-rs, 
      phenylalanine hydroxylase and src family associated phosphoprotein 2. A similar 
      analysis in the brain (cerebellum) involved complement component 1q (alpha 
      polypeptide), complement component 4, P lysozyme structural, glial fibrillary 
      acidic protein and cathepsin S. Caloric restriction (CR) inhibited age-related 
      expression of these genes in both tissues. Parametric analysis of gene set 
      enrichment identified several biological processes that are induced with aging in 
      multiple mouse strains. We also tested the ability of dietary antioxidants to 
      oppose these transcriptional markers of aging. Lycopene, resveratrol, 
      acetyl-l-carnitine and tempol were as effective as CR in the heart, and 
      alpha-lipoic acid and coenzyme Q(10) were as effective as CR in the cerebellum. 
      These findings suggest that transcriptional biomarkers of aging in mice can be 
      used to estimate the efficacy of aging interventions on a tissue-specific basis.
FAU - Park, Sang-Kyu
AU  - Park SK
AD  - Department of Genetics and Medical Genetics, University of Wisconsin, Madison, 
      53706, USA.
FAU - Kim, Kyoungmi
AU  - Kim K
FAU - Page, Grier P
AU  - Page GP
FAU - Allison, David B
AU  - Allison DB
FAU - Weindruch, Richard
AU  - Weindruch R
FAU - Prolla, Tomas A
AU  - Prolla TA
LA  - eng
GR  - R01 AG020681/AG/NIA NIH HHS/United States
GR  - R01 AG020681-05/AG/NIA NIH HHS/United States
GR  - R01AG020681/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090625
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Antioxidants/*administration & dosage
MH  - Biomarkers
MH  - Brain/metabolism
MH  - Caloric Restriction
MH  - *Diet
MH  - Gene Expression/drug effects
MH  - Gene Expression Profiling
MH  - Kinetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Myocardium/metabolism
MH  - Organ Specificity
MH  - Transcription, Genetic
PMC - PMC2733852
MID - NIHMS134507
EDAT- 2009/06/27 09:00
MHDA- 2009/10/27 06:00
PMCR- 2010/08/01
CRDT- 2009/06/27 09:00
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2009/10/27 06:00 [medline]
PHST- 2010/08/01 00:00 [pmc-release]
AID - ACE496 [pii]
AID - 10.1111/j.1474-9726.2009.00496.x [doi]
PST - ppublish
SO  - Aging Cell. 2009 Aug;8(4):484-95. doi: 10.1111/j.1474-9726.2009.00496.x. Epub 
      2009 Jun 25.