PMID- 19555773
OWN - NLM
STAT- MEDLINE
DCOM- 20091211
LR  - 20090728
IS  - 1879-1107 (Electronic)
IS  - 1096-4959 (Linking)
VI  - 154
IP  - 2
DP  - 2009 Oct
TI  - Tissue-specific and embryonic expression of the retinoid X receptors in 
      Sebastiscus marmoratus.
PG  - 221-8
LID - 10.1016/j.cbpb.2009.06.006 [doi]
AB  - Retinoid X receptors (RXRs) are highly conserved members of the nuclear receptor 
      family and mediate various physiological processes in vertebrates. Most studies 
      on RXRs have concentrated on their structure and function in mammals and their 
      characterization and developmental expression in Danio rerio. However, there is 
      little information concerning the distribution of RXRs in teleost tissues. In the 
      present study, we cloned partial sequences of three RXR subtypes (RXRa, -b, -g) 
      from Sebastiscus marmoratus by RACE PCR and analyzed the phylogeny of the teleost 
      and the tetrapod RXR genes, and identified some inconsistencies with previous 
      studies. The tissue-specific and embryonic expression profiles of each RXR gene 
      were explored using real time quantitative PCR. This analysis demonstrated that 
      these RXRs were expressed in all test tissues indicating their participation in 
      many physiological processes. However, we found a great difference in the 
      distribution of RXRg between teleosts and mammals. Furthermore, we followed 
      expression of the three subtypes through various embryo developmental stages and 
      found that the RXRa orthologues of teleosts might be involved in the development 
      of the anterior hindbrain, tailbud and neural crest and in the formation of the 
      pharynx and fin, that RXRb played ubiquitous roles in fish early development, and 
      that RXRg probably played a role in brain and nervous system development and 
      function.
FAU - He, Chengyong
AU  - He C
AD  - Key Laboratory of the Ministry of Education for Coast and Wetland Ecosystems, 
      School of Life Sciences, Xiamen University, Xiamen 361005, PR China.
FAU - Wang, Chonggang
AU  - Wang C
FAU - Li, Bowen
AU  - Li B
FAU - Xie, Fazhi
AU  - Xie F
FAU - Chen, Yixin
AU  - Chen Y
FAU - Zuo, Zhenghong
AU  - Zuo Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090623
PL  - England
TA  - Comp Biochem Physiol B Biochem Mol Biol
JT  - Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
JID - 9516061
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cloning, Molecular
MH  - Fishes/*embryology/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Phylogeny
MH  - Retinoid X Receptors/chemistry/*genetics
MH  - Sequence Alignment
EDAT- 2009/06/27 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/06/27 09:00
PHST- 2009/03/23 00:00 [received]
PHST- 2009/06/10 00:00 [revised]
PHST- 2009/06/14 00:00 [accepted]
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S1096-4959(09)00163-8 [pii]
AID - 10.1016/j.cbpb.2009.06.006 [doi]
PST - ppublish
SO  - Comp Biochem Physiol B Biochem Mol Biol. 2009 Oct;154(2):221-8. doi: 
      10.1016/j.cbpb.2009.06.006. Epub 2009 Jun 23.