PMID- 19556004
OWN - NLM
STAT- MEDLINE
DCOM- 20091014
LR  - 20131121
IS  - 1532-2785 (Electronic)
IS  - 0143-4179 (Linking)
VI  - 43
IP  - 4
DP  - 2009 Aug
TI  - Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of 
      morphine in nociception in neuropathic rats: behavioral and neuroanatomical 
      correlates.
PG  - 303-14
LID - 10.1016/j.npep.2009.05.003 [doi]
AB  - Although morphine is a potent antinociceptive agent, its chronic use developed 
      tolerance in neuropathic pain (NP). Furthermore, opioid antagonist naloxone 
      attenuated the antinociceptive effect of neuropeptide Y (NPY). The present study 
      investigated the role of NPY and NPY Y1/Y5 receptors in acute and chronic actions 
      of morphine in neuropathic rats using thermal paw withdrawal test and 
      immunocytochemistry. In acute study, intracerebroventricular (icv) administration 
      of morphine, NPY or NPY Y1/Y5 receptors agonist [Leu(31),Pro(34)]-NPY produced 
      antinociception, whereas selective NPY Y1 receptors antagonist BIBP3226 caused 
      hyperalgesia. While NPY or [Leu(31),Pro(34)]-NPY potentiated, BIBP3226 attenuated 
      morphine induced antinociception. Chronic icv infusion of morphine via osmotic 
      minipumps developed tolerance to its antinociceptive effect, and produced 
      hyperalgesia following withdrawal. However, co-administration of NPY or 
      [Leu(31),Pro(34)]-NPY prevented the development of tolerance and withdrawal 
      hyperalgesia. Sciatic nerve ligation resulted in significant increase in the 
      NPY-immunoreactive (NPY-ir) fibers in ventrolateral periaqueductal gray (VLPAG) 
      and locus coeruleus (LC); fibers in the dorsal part of dorsal raphe nucleus (DRD) 
      did not respond. While chronic morphine treatment significantly reduced NPY-ir 
      fibers in VLPAG and DRD, morphine withdrawal triggered significant augmentation 
      in NPY-immunoreactivity in the VLPAG. NPY-immunoreactivity profile of LC remained 
      unchanged in all the morphine treatment conditions. Furthermore, removal of 
      sciatic nerve ligation reversed the effects of NP, increased pain threshold and 
      restored NPY-ir fiber population in VLPAG. NPY, perhaps acting via Y1/Y5 
      receptors, might profoundly influence the processing of NP information and 
      interact with the endogenous opioid system primarily within the framework of the 
      VLPAG.
FAU - Upadhya, Manoj A
AU  - Upadhya MA
AD  - Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur 
      University Campus, Nagpur 440 033, India.
FAU - Dandekar, Manoj P
AU  - Dandekar MP
FAU - Kokare, Dadasaheb M
AU  - Kokare DM
FAU - Singru, Praful S
AU  - Singru PS
FAU - Subhedar, Nishikant K
AU  - Subhedar NK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090624
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Analgesics, Opioid)
RN  - 0 (BIBP 3226)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - 76I7G6D29C (Morphine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Analgesics, Opioid/*therapeutic use
MH  - Animals
MH  - Arginine/analogs & derivatives/metabolism
MH  - Behavior, Animal/*physiology
MH  - Drug Tolerance
MH  - Hyperalgesia/*drug therapy/physiopathology
MH  - Male
MH  - Morphine/*therapeutic use
MH  - Neuropeptide Y/chemistry/*metabolism
MH  - Pain Measurement
MH  - Peripheral Nervous System Diseases/pathology/physiopathology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Neuropeptide Y/agonists/antagonists & inhibitors/*metabolism
MH  - Sciatic Nerve/pathology/physiopathology
MH  - Substance Withdrawal Syndrome/*physiopathology
EDAT- 2009/06/27 09:00
MHDA- 2009/10/15 06:00
CRDT- 2009/06/27 09:00
PHST- 2009/02/04 00:00 [received]
PHST- 2009/05/14 00:00 [revised]
PHST- 2009/05/20 00:00 [accepted]
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2009/10/15 06:00 [medline]
AID - S0143-4179(09)00049-3 [pii]
AID - 10.1016/j.npep.2009.05.003 [doi]
PST - ppublish
SO  - Neuropeptides. 2009 Aug;43(4):303-14. doi: 10.1016/j.npep.2009.05.003. Epub 2009 
      Jun 24.