PMID- 19556042
OWN - NLM
STAT- MEDLINE
DCOM- 20091116
LR  - 20220330
IS  - 1523-6838 (Electronic)
IS  - 0272-6386 (Print)
IS  - 0272-6386 (Linking)
VI  - 54
IP  - 5
DP  - 2009 Nov
TI  - Idiopathic nephrotic syndrome and atopy: is there a common link?
PG  - 945-53
LID - 10.1053/j.ajkd.2009.03.019 [doi]
AB  - Numerous reports during the last 60 years have reported a strong association 
      between idiopathic nephrotic syndrome and atopic disorders. Idiopathic nephrotic 
      syndrome can be precipitated by allergic reactions and has been associated with 
      both aeroallergens (pollens, mold, and dust) and food allergies. Patients with 
      idiopathic nephrotic syndrome also may show increased serum immunoglobulin E 
      (IgE) levels. A review of the literature suggests that although some idiopathic 
      nephrotic syndrome cases may be associated with allergies, evidence that it is a 
      type of allergic disorder or can be induced by a specific allergen is weak. 
      Rather, it is likely that the proteinuria and increased IgE levels in patients 
      with idiopathic nephrotic syndrome are caused by increased levels of interleukin 
      13 observed in these patients. Recent studies suggest that interleukin 13, a 
      known stimulator of IgE response, may mediate proteinuria in patients with 
      minimal change disease because of its ability to directly induce CD80 expression 
      on the podocyte.
FAU - Abdel-Hafez, Maher
AU  - Abdel-Hafez M
AD  - Division of Pediatric Nephrology, University of Florida, Gainesville, FL 32610, 
      USA.
FAU - Shimada, Michiko
AU  - Shimada M
FAU - Lee, Pui Y
AU  - Lee PY
FAU - Johnson, Richard J
AU  - Johnson RJ
FAU - Garin, Eduardo H
AU  - Garin EH
LA  - eng
GR  - R01 DK052121/DK/NIDDK NIH HHS/United States
GR  - R01 DK052121-13/DK/NIDDK NIH HHS/United States
GR  - R01 HL068607/HL/NHLBI NIH HHS/United States
GR  - R01 HL068607-08/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20090625
PL  - United States
TA  - Am J Kidney Dis
JT  - American journal of kidney diseases : the official journal of the National Kidney 
      Foundation
JID - 8110075
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Humans
MH  - Hypersensitivity, Immediate/*complications
MH  - Immunoglobulin E/immunology
MH  - Nephrosis, Lipoid/complications/immunology
MH  - Nephrotic Syndrome/*etiology/immunology
PMC - PMC2895907
MID - NIHMS149473
EDAT- 2009/06/27 09:00
MHDA- 2009/11/17 06:00
PMCR- 2010/07/02
CRDT- 2009/06/27 09:00
PHST- 2008/12/10 00:00 [received]
PHST- 2009/03/20 00:00 [accepted]
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2009/11/17 06:00 [medline]
PHST- 2010/07/02 00:00 [pmc-release]
AID - S0272-6386(09)00648-9 [pii]
AID - 10.1053/j.ajkd.2009.03.019 [doi]
PST - ppublish
SO  - Am J Kidney Dis. 2009 Nov;54(5):945-53. doi: 10.1053/j.ajkd.2009.03.019. Epub 
      2009 Jun 25.