PMID- 19556716
OWN - NLM
STAT- MEDLINE
DCOM- 20091021
LR  - 20190608
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 16
IP  - 3
DP  - 2009 Jun
TI  - Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery 
      disease severity in Japanese men.
PG  - 194-200
AB  - AIM: ATP-binding cassette transporter G1 (ABCG1) is a cholesterol transporter 
      that plays a role in cholesterol efflux in the presence of high-density 
      lipoprotein (HDL). Moreover, HDL-mediated cholesterol efflux is increased in 
      cultured ABCG1 overexpressed cells; however, the physiological roles of ABCG1 and 
      its contribution to atherosclerosis in humans remain unclear. METHODS: The effect 
      of ABCG1 -257T>G mutation on transcription activity was determined by a reporter 
      assay. One hundred nine Japanese men with coronary artery disease (CAD) were 
      analyzed. ABCG1 -257T>G polymorphism was assessed by mutation-selective PCR 
      methods to identify T/T, T/G, and G/G genotypes. RESULTS: The reporter assay 
      showed that ABCG1 transcription activity was significantly lower (p<0.01) in the 
      G allele of -257T>G polymorphism compared with that in the T allele. Clinically, 
      there were no significant differences in serum triglyceride and total, LDL, and 
      HDL cholesterol levels, or other risk factors. Logistic regression analysis 
      revealed significant additive and dominant effects on the frequency of patients 
      with multi-vessel disease compared with single-vessel disease (T/T vs. T/G vs. 
      G/G, odds ratio:2.1, p=0.027; T/T vs. T/G and. G/G, odds ratio:3.5, p=0.005). 
      CONCLUSION: This is the first report to show that a novel ABCG1 -257T>G promoter 
      polymorphism influences CAD severity in Japanese men.
FAU - Furuyama, Shoudai
AU  - Furuyama S
AD  - Department of Cardiology, Fukuoka University Faculty of Medicine, Fukuoka 
      814-0180, Japan.
FAU - Uehara, Yoshinari
AU  - Uehara Y
FAU - Zhang, Bo
AU  - Zhang B
FAU - Baba, Yasuhiko
AU  - Baba Y
FAU - Abe, Satomi
AU  - Abe S
FAU - Iwamoto, Takahiro
AU  - Iwamoto T
FAU - Miura, Shin-Ichiro
AU  - Miura S
FAU - Saku, Keijiro
AU  - Saku K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090626
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Aged
MH  - Coronary Artery Disease/epidemiology/*genetics/pathology
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Mutagenesis, Site-Directed
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Transcription, Genetic
EDAT- 2009/06/27 09:00
MHDA- 2009/10/22 06:00
CRDT- 2009/06/27 09:00
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2009/10/22 06:00 [medline]
AID - JST.JSTAGE/jat/E380 [pii]
AID - 10.5551/jat.e380 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2009 Jun;16(3):194-200. doi: 10.5551/jat.e380. Epub 2009 
      Jun 26.