PMID- 19557358
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20181201
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 32
IP  - 6
DP  - 2009 Jun
TI  - Anti-allergic effects of white rose petal extract and anti-atopic properties of 
      its hexane fraction.
PG  - 823-30
LID - 10.1007/s12272-009-1602-6 [doi]
AB  - Rosa rugosa is a species of rose native to eastern Asia. The root of R. rugosa 
      has been used to treat diabetes mellitus, pain and chronic inflammatory disease, 
      and a R. rugosa petal extract has a strong anti-oxidant effect. In the present 
      study, we examined if solvent fractions from white rose petal extract (WRPE) had 
      any anti-allergic or anti-atopic effects not previously reported. WRPE and 
      butanol and hexane fractions effectively reduced systemic anaphylactic reactions 
      and anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis in mice, 
      with the greatest inhibition observed for the hexane fraction. In addition, a 
      significant reduction of scratching behavior by mice after histamine injection 
      suggested this fraction's potential anti-allergic effect. At the cell level, the 
      hexane fraction markedly inhibited beta-hexosaminidase release from RBL-2H3 mast 
      cells and suppressed the expressions of mRNA interferon-gamma and interleukin-4 
      cytokines produced by T helper cells (type 1 and 2). These results strongly 
      support that the hexane fraction may have an effect on atopic dermatitis, as 
      these 2 cell types play central roles in the pathogenesis of atopic dermatitis. 
      In conclusion, these results suggest that either the hexane fraction or one of 
      its components may be beneficial for the treatment of allergic diseases, 
      including atopic dermatitis.
FAU - Jeon, Jeong Hee
AU  - Jeon JH
AD  - College of Veterinary Medicine and Research Institute of Veterinary Medicine, 
      Chungbuk National University, Cheongju 361-763, Korea.
FAU - Kwon, Sang-Chul
AU  - Kwon SC
FAU - Park, Dongsun
AU  - Park D
FAU - Shin, Sunhee
AU  - Shin S
FAU - Jeong, Jae-Hyun
AU  - Jeong JH
FAU - Park, So-Young
AU  - Park SY
FAU - Hwang, Seock-Yeon
AU  - Hwang SY
FAU - Kim, Yun-Bae
AU  - Kim YB
FAU - Joo, Seong Soo
AU  - Joo SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090626
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Hexanes)
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Anaphylaxis/chemically induced/drug therapy
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Drug Evaluation, Preclinical
MH  - Flowers/chemistry
MH  - Hexanes/isolation & purification/*pharmacology
MH  - Histamine/pharmacology
MH  - Hypersensitivity, Immediate/*drug therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred ICR
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - *Phytotherapy
MH  - Plant Extracts/*pharmacology
MH  - *Rosa
MH  - Spleen/drug effects/metabolism
MH  - beta-N-Acetylhexosaminidases/metabolism
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2009/06/27 09:00
MHDA- 2009/08/11 09:00
CRDT- 2009/06/27 09:00
PHST- 2009/03/05 00:00 [received]
PHST- 2009/05/20 00:00 [accepted]
PHST- 2009/04/29 00:00 [revised]
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
AID - 10.1007/s12272-009-1602-6 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2009 Jun;32(6):823-30. doi: 10.1007/s12272-009-1602-6. Epub 2009 
      Jun 26.