PMID- 19557639
OWN - NLM
STAT- MEDLINE
DCOM- 20090902
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 50
IP  - 7
DP  - 2009 Jul
TI  - Function of retinoid acid receptor alpha and p21 in all-trans-retinoic 
      acid-induced acute T-lymphoblastic leukemia apoptosis.
PG  - 1183-9
LID - 10.1080/10428190902934936 [doi]
AB  - All-trans-retinoic acid (ATRA) is a morphogenetic signalling molecule derived 
      from vitamin A and is used clinically to target acute promyelocytic leukemia by 
      inducing differentiation of immature blood cells. Retinoid signals are mediated 
      by retinoic acid (RA) receptors (RARs) and retinoid X receptors (RXRs). Retinoic 
      acid receptors consist of RARalpha, RARbeta and RARgamma isotypes. Among these 
      components, RARalpha is preferentially bound to ATRA, which is used to treat 
      acute T-lymphoblastic leukemia, yet the conditions and mechanisms remain unknown. 
      In this study, we have demonstrated that, in human acute T-lymphoblastic leukemia 
      Molt3 cells, inhibition of RA-induced proliferation results from massive cell 
      death characterised by apoptosis. The effect of ATRA:RARalpha binding on 
      apoptosis in Molt3 cells has been investigated. Consequently, it has been shown 
      that, in RA-treated Molt3 cells, upregulation of p21 due to RA accompanies 
      caspase 3/PARP activation which precedes the occurrence of apoptosis.
FAU - Luo, Peihua
AU  - Luo P
AD  - Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, 
      Zhejiang University, Hangzhou, People's Republic of China.
FAU - Lin, Meili
AU  - Lin M
FAU - Lin, Meihua
AU  - Lin M
FAU - Chen, Yiyu
AU  - Chen Y
FAU - Yang, Bo
AU  - Yang B
FAU - He, Qiaojun
AU  - He Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (CDKN1A protein, human)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (RARA protein, human)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
RIN - Leuk Lymphoma. 2016 May;57(5):1243. PMID: 26949131
MH  - *Apoptosis
MH  - Caspases/metabolism
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Cyclin-Dependent Kinase Inhibitor p21/*physiology
MH  - Densitometry/methods
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Leukemia, Biphenotypic, Acute/*metabolism/*pathology
MH  - Models, Biological
MH  - Poly(ADP-ribose) Polymerases/metabolism
MH  - Receptors, Retinoic Acid/*physiology
MH  - Retinoic Acid Receptor alpha
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tretinoin/*metabolism
EDAT- 2009/06/27 09:00
MHDA- 2009/09/03 06:00
CRDT- 2009/06/27 09:00
PHST- 2009/06/27 09:00 [entrez]
PHST- 2009/06/27 09:00 [pubmed]
PHST- 2009/09/03 06:00 [medline]
AID - 912711107 [pii]
AID - 10.1080/10428190902934936 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2009 Jul;50(7):1183-9. doi: 10.1080/10428190902934936.