PMID- 19558782
OWN - NLM
STAT- MEDLINE
DCOM- 20090715
LR  - 20151119
IS  - 0963-6897 (Print)
IS  - 0963-6897 (Linking)
VI  - 18
IP  - 3
DP  - 2009
TI  - Autologous bone-marrow mononuclear cell transplantation after acute myocardial 
      infarction: comparison of two delivery techniques.
PG  - 343-52
LID - 10.3727/096368909788534951 [doi]
AB  - The objective of this study was to investigate safety and feasibility of 
      autologous bone marrow mononuclear cells (BMMNC) transplantation in ST elevation 
      myocardial infarction (STEMI), comparing anterograde intracoronary artery (ICA) 
      delivery with retrograde intracoronary vein (ICV) approach. An open labeled, 
      randomized controlled trial of 30 patients admitted with STEMI was used. Patients 
      were enrolled if they 1) were successfully reperfused within 24 h from symptoms 
      onset and 2) had infarct size larger than 10% of the left ventricle (LV). One 
      hundred million BMMNC were injected in the infarct-related artery (intra-arterial 
      group) or vein (intravenous group), 1% of which was labeled with 
      Tc(99m)-hexamethylpropylenamineoxime. Cell distribution was evaluated 4 and 24 h 
      after injection. Baseline MRI was performed in order to evaluate microbstruction 
      pattern. Baseline radionuclide ventriculography was performed before cell 
      transfer and after 3 and 6 months. All the treated patients were submitted to 
      repeat coronary angiography after 3 months. Thirty patients (57 +/- 11 years, 70% 
      males) were randomly assigned to ICA (n = 14), ICV (n = 10), or control (n = 6) 
      groups. No serious adverse events related to the procedure were observed. Early 
      and late retention of radiolabeled cells was higher in the ICA than in the ICV 
      group, independently of microcirculation obstruction. An increase of EF was 
      observed in the ICA group (p = 0.02) compared to baseline. Injection procedures 
      through anterograde and retrograde approaches seem to be feasible and safe. BMMNC 
      retention by damaged heart tissue was apparently higher when the anterograde 
      approach was used. Further studies are required to confirm these initial data.
FAU - Silva, Suzana A
AU  - Silva SA
AD  - Teaching and Research Center of Pro-Cardiaco/PROCEP, Rio de Janeiro, Brazil.
FAU - Sousa, Andre L S
AU  - Sousa AL
FAU - Haddad, Andrea F
AU  - Haddad AF
FAU - Azevedo, Jader C
AU  - Azevedo JC
FAU - Soares, Vinicio E
AU  - Soares VE
FAU - Peixoto, Cintia M
AU  - Peixoto CM
FAU - Soares, Ana J S
AU  - Soares AJ
FAU - Issa, Aurora F C
AU  - Issa AF
FAU - Felipe, Luis Renato V
AU  - Felipe LR
FAU - Branco, Rodrigo V C
AU  - Branco RV
FAU - Addad, Joao A
AU  - Addad JA
FAU - Moreira, Rodrigo C
AU  - Moreira RC
FAU - Tuche, Fabio A A
AU  - Tuche FA
FAU - Mesquita, Claudio T
AU  - Mesquita CT
FAU - Drumond, Cristina C O
AU  - Drumond CC
FAU - Junior, Amarino O
AU  - Junior AO
FAU - Rochitte, Carlos E
AU  - Rochitte CE
FAU - Luz, Jose H M
AU  - Luz JH
FAU - Rabischoffisky, Arnaldo
AU  - Rabischoffisky A
FAU - Nogueira, Fernanda B
AU  - Nogueira FB
FAU - Vieira, Rosana B C
AU  - Vieira RB
FAU - Junior, Hamilton S
AU  - Junior HS
FAU - Borojevic, Radovan
AU  - Borojevic R
FAU - Dohmann, Hans F R
AU  - Dohmann HF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Transplant
JT  - Cell transplantation
JID - 9208854
RN  - 0 (Nitrates)
RN  - 3B744AG22N (Technetium Tc 99m Exametazime)
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow Transplantation/*methods
MH  - Demography
MH  - Female
MH  - Humans
MH  - Injections
MH  - Leukocytes, Mononuclear/*transplantation
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*therapy
MH  - Nitrates
MH  - Radionuclide Ventriculography
MH  - Technetium Tc 99m Exametazime
MH  - Technetium Tc 99m Sestamibi
MH  - Transplantation, Autologous
EDAT- 2009/06/30 09:00
MHDA- 2009/07/16 09:00
CRDT- 2009/06/30 09:00
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/07/16 09:00 [medline]
AID - 10.3727/096368909788534951 [doi]
PST - ppublish
SO  - Cell Transplant. 2009;18(3):343-52. doi: 10.3727/096368909788534951.