PMID- 19559014
OWN - NLM
STAT- MEDLINE
DCOM- 20090925
LR  - 20091119
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1289
DP  - 2009 Sep 15
TI  - rPer1 and rPer2 induction during phases of the circadian cycle critical for light 
      resetting of the circadian clock.
PG  - 37-48
LID - 10.1016/j.brainres.2009.06.051 [doi]
AB  - Photic resetting of a biological clock is one of the fundamental characteristics 
      of circadian systems and allows living organisms to adjust to a particular 
      environment. Nocturnal light induces the Per1 and Per2 genes, which leads to a 
      resetting of the circadian clock in the suprachiasmatic nucleus (SCN), the 
      mammalian circadian center. In our present study, we investigated whether light 
      differentially induces the rat Per1 (rPer1) and Per2 (rPer2) genes to enable 
      resetting of their circadian clocks. In a 24-hour LD cycle (12 h light:12 h 
      dark), which is shorter than the normal free-running period for rats, Per1 alone 
      showed strong induction in the ventrolateral region of the SCN (VLSCN) during the 
      early day. In contrast, in a 25 hour LD cycle (12.5 h light:12.5 h dark), which 
      is longer than the free running period for these animals, rPer2 alone was 
      strongly induced in the VLSCN, at the end of the light phase and during the early 
      dark periods. Our current findings therefore suggest that Per1 and Per2 are 
      differentially regulated for daily entrainment to the LD cycle.
FAU - Nagano, Mamoru
AU  - Nagano M
AD  - Department of Anatomy and Neurobiology, Kinki University School of Medicine 377-2 
      Ohno-Higashi, Osakasayama City, Osaka 589-8511, Japan.
FAU - Adachi, Akihito
AU  - Adachi A
FAU - Masumoto, Koh-hei
AU  - Masumoto KH
FAU - Meyer-Bernstein, Elizabeth
AU  - Meyer-Bernstein E
FAU - Shigeyoshi, Yasufumi
AU  - Shigeyoshi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090624
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Per1 protein, rat)
RN  - 0 (Per2 protein, rat)
RN  - 0 (Period Circadian Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Cell Cycle Proteins/*genetics/metabolism
MH  - Circadian Rhythm/*genetics
MH  - Darkness
MH  - In Situ Hybridization
MH  - Intracellular Signaling Peptides and Proteins/*genetics/metabolism
MH  - Male
MH  - Motor Activity/genetics
MH  - Nuclear Proteins/*genetics/metabolism
MH  - Period Circadian Proteins
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Suprachiasmatic Nucleus/*metabolism
MH  - Time Factors
EDAT- 2009/06/30 09:00
MHDA- 2009/09/26 06:00
CRDT- 2009/06/30 09:00
PHST- 2008/12/08 00:00 [received]
PHST- 2009/06/15 00:00 [revised]
PHST- 2009/06/17 00:00 [accepted]
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/09/26 06:00 [medline]
AID - S0006-8993(09)01267-0 [pii]
AID - 10.1016/j.brainres.2009.06.051 [doi]
PST - ppublish
SO  - Brain Res. 2009 Sep 15;1289:37-48. doi: 10.1016/j.brainres.2009.06.051. Epub 2009 
      Jun 24.