PMID- 19559074
OWN - NLM
STAT- MEDLINE
DCOM- 20091026
LR  - 20090804
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 462
IP  - 3
DP  - 2009 Oct 25
TI  - Effects of a high-frequency, low-intensity, biphasic conditioning train of TMS 
      pulses on the human motor cortex.
PG  - 188-92
LID - 10.1016/j.neulet.2009.06.062 [doi]
AB  - Intracortical circuit excitability of the human motor cortex has been studied by 
      measuring effects of some conditioning TMS stimulus on the succeeding test TMS 
      stimulus in the motor cortex, such as short-interval intracortical inhibition 
      (SICI) and intracortical facilitation (ICF). A single-pulse TMS was used as a 
      conditioning stimulus (CS) in these techniques, but a train of several TMS pulses 
      might induce some intracortical changes in the motor cortex more effectively. For 
      nine healthy volunteers, we compared the SICI and ICF induced by a single 
      conditioning biphasic TMS pulse with those induced by a train of 10 biphasic TMS 
      pulses of the same intensity. As a conditioning stimulus, we delivered a 
      subthreshold single biphasic pulse (CS1) or 10, 10-Hz biphasic pulses (CS10) 
      before a suprathreshold monophasic test stimulus at several interstimulus 
      intervals (ISIs) of 3-40 ms over the hand motor area. The CS intensity was 
      50-100% of the active motor threshold (AMT). We compared the motor cortical 
      excitability after the conditioning stimulus (single pulse or a train of ten 
      pulses) at the intervals for SICI and ICF. A train of ten 10-Hz pulses elicited 
      greater inhibition at short ISIs than a single conditioning pulse did. The 
      facilitation at ISIs around 10 ms corresponding to the ICF was evoked by CS1 only 
      at an intensity of 80% AMT; CS10 evoked no ICF. Furthermore, CS10 evoked MEP 
      inhibition at longer intervals. Results show that a train of high-frequency, 
      low-intensity, biphasic TMS pulses can have a strong inhibitory effect on the 
      motor cortex.
FAU - Arai, Noritoshi
AU  - Arai N
AD  - Department of Neurology, Division of Neuroscience, Graduate School of Medicine, 
      The University of Tokyo, Tokyo, Japan. araino@hotmail.com
FAU - Furubayashi, Toshiaki
AU  - Furubayashi T
FAU - Inomata-Terada, Satomi
AU  - Inomata-Terada S
FAU - Okabe, Shingo
AU  - Okabe S
FAU - Kobayashi-Iwata, Nobue
AU  - Kobayashi-Iwata N
FAU - Hanajima, Ritsuko
AU  - Hanajima R
FAU - Terao, Yasuo
AU  - Terao Y
FAU - Ugawa, Yoshikazu
AU  - Ugawa Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090624
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition
MH  - Transcranial Magnetic Stimulation
EDAT- 2009/06/30 09:00
MHDA- 2009/10/27 06:00
CRDT- 2009/06/30 09:00
PHST- 2008/10/29 00:00 [received]
PHST- 2009/06/17 00:00 [revised]
PHST- 2009/06/19 00:00 [accepted]
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/10/27 06:00 [medline]
AID - S0304-3940(09)00849-0 [pii]
AID - 10.1016/j.neulet.2009.06.062 [doi]
PST - ppublish
SO  - Neurosci Lett. 2009 Oct 25;462(3):188-92. doi: 10.1016/j.neulet.2009.06.062. Epub 
      2009 Jun 24.