PMID- 19560099
OWN - NLM
STAT- MEDLINE
DCOM- 20090922
LR  - 20220408
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Print)
IS  - 1552-5260 (Linking)
VI  - 5
IP  - 4
DP  - 2009 Jul
TI  - Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice.
PG  - 287-94
LID - 10.1016/j.jalz.2009.02.006 [doi]
AB  - BACKGROUND: Human studies on exercise, cognition, and apolipoprotein E (APOE) 
      genotype show that epsilon4 carriers may benefit from regular physical activity. 
      METHODS: We examined voluntary wheel-running, memory, and hippocampal plasticity 
      in APOE epsilon3 and APOE epsilon4 transgenic mice at 10-12 months of age. 
      RESULTS: Sedentary epsilon4 mice exhibited deficits in cognition on the 
      radial-arm water maze (RAWM), a task dependent on the hippocampus. Six weeks of 
      wheel-running in epsilon4 mice resulted in improvements on the RAWM to the level 
      of epsilon3 mice. Hippocampal brain-derived neurotrophic factor (BDNF) levels 
      were similar in epsilon3 and epsilon4 mice, and after exercise BDNF was similarly 
      increased in both epsilon3 and epsilon4 mice. In sedentary epsilon4 mice, 
      tyrosine kinase B (Trk B) receptors were reduced by 50%. Exercise restored Trk B 
      in epsilon4 mice to the level of epsilon3 mice, and in epsilon4 mice, exercise 
      dramatically increased synaptophysin, a marker of synaptic function. CONCLUSIONS: 
      Our results support the hypothesis that exercise can improve cognitive function, 
      particularly in epsilon4 carriers.
FAU - Nichol, Kathryn
AU  - Nichol K
AD  - Institute for Brain Aging and Dementia, University of California, Irvine, CA, 
      USA. k8nichol@gmail.com
FAU - Deeny, Sean P
AU  - Deeny SP
FAU - Seif, Joseph
AU  - Seif J
FAU - Camaclang, Kevin
AU  - Camaclang K
FAU - Cotman, Carl W
AU  - Cotman CW
LA  - eng
GR  - AG000096-26/AG/NIA NIH HHS/United States
GR  - P01 AG000538/AG/NIA NIH HHS/United States
GR  - AR47752-06/AR/NIAMS NIH HHS/United States
GR  - T32 AR047752/AR/NIAMS NIH HHS/United States
GR  - T32 AG000096/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
RN  - 0 (Apolipoprotein E3)
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Synaptophysin)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Alzheimer Disease/genetics/metabolism/therapy
MH  - Animals
MH  - Apolipoprotein E3/metabolism
MH  - Apolipoprotein E4/*genetics
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*physiology
MH  - Cognition Disorders/genetics/metabolism/therapy
MH  - Disease Models, Animal
MH  - Exercise Therapy/*methods
MH  - Genetic Predisposition to Disease/genetics
MH  - Heterozygote
MH  - Hippocampus/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Neural Pathways/physiology
MH  - Neurogenesis/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Physical Conditioning, Animal/*methods
MH  - Receptor, trkB/metabolism
MH  - Synaptophysin/metabolism
MH  - Treatment Outcome
MH  - Up-Regulation/physiology
PMC - PMC4105011
MID - NIHMS581379
EDAT- 2009/06/30 09:00
MHDA- 2009/09/23 06:00
PMCR- 2014/07/21
CRDT- 2009/06/30 09:00
PHST- 2008/06/26 00:00 [received]
PHST- 2009/02/18 00:00 [revised]
PHST- 2009/02/19 00:00 [accepted]
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/09/23 06:00 [medline]
PHST- 2014/07/21 00:00 [pmc-release]
AID - S1552-5260(09)00060-0 [pii]
AID - 10.1016/j.jalz.2009.02.006 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2009 Jul;5(4):287-94. doi: 10.1016/j.jalz.2009.02.006.