PMID- 19560209
OWN - NLM
STAT- MEDLINE
DCOM- 20091005
LR  - 20131121
IS  - 1873-3344 (Electronic)
IS  - 0162-0134 (Linking)
VI  - 103
IP  - 8
DP  - 2009 Aug
TI  - Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and 
      solvent effects on the biological activity.
PG  - 1113-9
LID - 10.1016/j.jinorgbio.2009.05.009 [doi]
AB  - A series of new platinum(II) amidine derivatives of the type 
      cis-[PtCl(2)Z-NHC(NHR)Me(2)] (R=cyclopropyl, 1; cyclopentyl, 2; cyclohexyl, 3) 
      were prepared in high yield by addition of the corresponding cyclic aliphatic 
      amine RNH(2) to the coordinated acetonitrile ligands in cis-[PtCl(2)(NCMe)(2)]. 
      The solution behaviour of 1-3 has been studied in DMSO, PEG 400 (polyethylene 
      glycol) and PEG-DME 500 (polyethylene glycol dimethylether). The amidine 
      complexes 1-3 were evaluated for their cytotoxic properties against a panel of 
      human tumor cell lines containing examples of cervix (HeLa), breast (MCF7), lung 
      (A549) and colon (HCT-15) cancer. Moreover, the amidine complexes were tested for 
      their cytotoxicity against normal human fibroblasts (HFF-1). For comparison 
      purposes, the cytotoxicity of cisplatin was examined under the same experimental 
      conditions. The results obtained showed that PEG and PEG-DME behave as good 
      solvents to carry out biological assays with platinum complexes which are 
      water-insoluble and unstable in DMSO. Complexes 2 and 3 exhibited a biological 
      activity comparable to that of cisplatin.
FAU - Marzano, Cristina
AU  - Marzano C
AD  - Department of Pharmaceutical Sciences, University of Padova, Italy.
FAU - Sbovata, Silvia Mazzega
AU  - Sbovata SM
FAU - Gandin, Valentina
AU  - Gandin V
FAU - Michelin, Rino A
AU  - Michelin RA
FAU - Venzo, Alfonso
AU  - Venzo A
FAU - Bertani, Roberta
AU  - Bertani R
FAU - Seraglia, Roberta
AU  - Seraglia R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090524
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Amidines)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Solutions)
RN  - 0 (Solvents)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Amidines/*chemistry
MH  - Antineoplastic Agents/chemical synthesis/chemistry/*toxicity
MH  - Cell Line, Tumor
MH  - Cisplatin/*chemical synthesis/chemistry/*toxicity
MH  - Heterocyclic Compounds/*chemistry
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Molecular Structure
MH  - Solutions
MH  - Solvents/*chemistry
EDAT- 2009/06/30 09:00
MHDA- 2009/10/06 06:00
CRDT- 2009/06/30 09:00
PHST- 2008/10/31 00:00 [received]
PHST- 2009/05/05 00:00 [revised]
PHST- 2009/05/06 00:00 [accepted]
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/10/06 06:00 [medline]
AID - S0162-0134(09)00098-1 [pii]
AID - 10.1016/j.jinorgbio.2009.05.009 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2009 Aug;103(8):1113-9. doi: 10.1016/j.jinorgbio.2009.05.009. 
      Epub 2009 May 24.