PMID- 19560330
OWN - NLM
STAT- MEDLINE
DCOM- 20091124
LR  - 20151119
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 103
IP  - 10
DP  - 2009 Oct
TI  - Depression and its relationship with poor exercise capacity, BODE index and 
      muscle wasting in COPD.
PG  - 1572-9
LID - 10.1016/j.rmed.2008.11.021 [doi]
AB  - BACKGROUND: The prevalence of depression in stable COPD patients varies markedly, 
      possibly because of use of different scales. We aimed to assess depression using 
      2 different depression scales and to examine the association between depression 
      and poor exercise performance, BODE index and muscle wasting in clinically stable 
      COPD patients. METHODS: 122 stable COPD patients were assessed with the Centre 
      for Epidemiologic Studies Depression Scale (CES-D) and the Brief Assessment 
      Schedule Depression Cards (BASDEC). We also assessed patients with spirometry, 
      bioelectrical impedance analysis, 6-minute walk distance (6MWD), St George's 
      Respiratory Questionnaire (SGRQ) and MRC dyspnoea and Borg scales. RESULTS: The 
      CES-D and BASDEC scales detected almost similar prevalence rates of depression 
      (21% vs 17%) with a Kappa coefficient of 0.68, p<0.0001. The BASDEC scale 
      detected more depression in women and was more closely associated with dyspnoea 
      than the CES-D. COPD severity was associated with depression when using BODE 
      scores but not when GOLD categories were used. Each of the CES-D and BASDEC 
      depression scores were associated with 6MWD after adjusting for FEV1% predicted, 
      gender, age and pack-years (p = <0.0001 and 0.001, respectively). Also, patients 
      with a 6MWD<350 scored significantly higher on both depression scales. Wasted 
      patients appeared to have higher depression scores, but the difference was 
      statistically insignificant. CONCLUSION: The administration of different 
      depression scales may affect some of the characteristics of depressed patients 
      rather than the prevalence rate of depression. Depression was associated with 
      poor exercise performance and BODE index in COPD.
FAU - Al-shair, Khaled
AU  - Al-shair K
AD  - Medicines Evaluation Unit, North West Lung Research Centre, Langley Building, 
      Southmoor Road, The University of Manchester, South Manchester University 
      Hospitals Trust, Wythenshawe, Manchester M23 9QZ, UK. 
      khaled.al-shair@postgrad.manchester.ac.uk
FAU - Dockry, Rachel
AU  - Dockry R
FAU - Mallia-Milanes, Brendan
AU  - Mallia-Milanes B
FAU - Kolsum, Umme
AU  - Kolsum U
FAU - Singh, Dave
AU  - Singh D
FAU - Vestbo, Jorgen
AU  - Vestbo J
LA  - eng
PT  - Journal Article
DEP - 20090626
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Aged
MH  - Airway Obstruction/physiopathology
MH  - Body Mass Index
MH  - Depressive Disorder/etiology/*psychology
MH  - Dyspnea/physiopathology
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Forced Expiratory Volume/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Pulmonary Disease, Chronic Obstructive/complications/*psychology/rehabilitation
MH  - Quality of Life/*psychology
MH  - Surveys and Questionnaires
EDAT- 2009/06/30 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/06/30 09:00
PHST- 2008/07/28 00:00 [received]
PHST- 2008/11/06 00:00 [revised]
PHST- 2008/11/07 00:00 [accepted]
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0954-6111(09)00188-7 [pii]
AID - 10.1016/j.rmed.2008.11.021 [doi]
PST - ppublish
SO  - Respir Med. 2009 Oct;103(10):1572-9. doi: 10.1016/j.rmed.2008.11.021. Epub 2009 
      Jun 26.