PMID- 19561024
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20091002
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 30
IP  - 19
DP  - 2009 Oct
TI  - Randomized controlled trial on the cardioprotective effect of bone marrow cells 
      in patients undergoing coronary bypass graft surgery.
PG  - 2354-9
LID - 10.1093/eurheartj/ehp262 [doi]
AB  - AIMS: This randomized study investigates whether bone marrow cells (BMCs) can 
      reduce ischaemic injury during cardiac surgery. METHODS AND RESULTS: Forty-four 
      elective coronary artery bypass grafting patients were randomized to control 
      group or BMCs group (whereby autologous BMCs were administered with each dose of 
      cardioplegia antegradely into the coronaries). Troponin I and CK-MB were measured 
      during the first 48 h after surgery and were not significantly different between 
      the control and BMCs groups. The role of cardiopulmonary bypass (CPB) on the 
      cardioprotective effects of BMCs was also studied using an in vitro model of 
      stimulated ischaemia and reoxygenation on right atrial appendages obtained from 
      controls either before or 10 min after the initiation of CPB. Bone marrow cells 
      significantly reduced myocardial injury in muscles obtained prior to CPB. This 
      effect was comparable with ischaemic preconditioning (IP), although their 
      combination did not afford additional benefit. However, when muscles were 
      harvested after CPB, myocardial injury in the ischaemic group alone was less, and 
      BMCs or IP did not exert further protection. CONCLUSION: Bone marrow cells did 
      not afford additional benefit when used as an additive to cardioplegia during 
      CPB. However, BMCs offer cardioprotection as potent as IP, when the heart is not 
      subjected to stress, such as CPB, that per se can precondition the myocardium.
FAU - Lai, Vien Khach
AU  - Lai VK
AD  - Cardiac Surgery Unit, Department of Cardiovascular Sciences, University of 
      Leicester, Clinical Science Wing, Glenfield Hospital, Leicester LE3 9QP, UK.
FAU - Ang, Keng-Leong
AU  - Ang KL
FAU - Rathbone, Wendy
AU  - Rathbone W
FAU - Harvey, Nicholas James
AU  - Harvey NJ
FAU - Galinanes, Manuel
AU  - Galinanes M
LA  - eng
GR  - PG04050/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20090626
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Troponin I)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Marrow Transplantation/*methods
MH  - Coronary Artery Bypass/*methods
MH  - Creatine Kinase, MB Form/metabolism
MH  - Female
MH  - Heart Arrest, Induced/methods
MH  - Humans
MH  - Ischemic Preconditioning, Myocardial/methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*prevention & control
MH  - Risk Factors
MH  - Troponin I/metabolism
MH  - Young Adult
EDAT- 2009/06/30 09:00
MHDA- 2010/07/16 06:00
CRDT- 2009/06/30 09:00
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - ehp262 [pii]
AID - 10.1093/eurheartj/ehp262 [doi]
PST - ppublish
SO  - Eur Heart J. 2009 Oct;30(19):2354-9. doi: 10.1093/eurheartj/ehp262. Epub 2009 Jun 
      26.