PMID- 19561044
OWN - NLM
STAT- MEDLINE
DCOM- 20090922
LR  - 20161018
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 161
IP  - 3
DP  - 2009 Sep
TI  - Influence of prematurity and growth restriction on the adipokine profile, IGF1, 
      and ghrelin levels in cord blood: relationship with glucose metabolism.
PG  - 381-9
LID - 10.1530/EJE-09-0193 [doi]
AB  - OBJECTIVE: To determine the influence of gestational age and fetal growth 
      restriction on the cord blood adipokine profile, IGF1, and ghrelin levels, and 
      their relationship with glucose metabolism. STUDY DESIGN: One hundred and ninety 
      newborns (99 preterm and 91 full term) were studied and, according to their 
      anthropometry at birth, classified as small (SGA) or adequate for gestational age 
      (AGA). METHODS: Venous cord blood serum levels of IGF1, IGF binding protein 3 
      (IGFBP-3), adiponectin, resistin, leptin, soluble leptin receptor (sOB-R), 
      tumoral necrosis factor-alpha, interleukin 6 (IL-6), total ghrelin, and acylated 
      ghrelin were determined and compared between preterm and full-term, as well as 
      between SGA and AGA, newborns. Correlations with newborn weight, gestational age, 
      and homeostatic model assessment (HOMA) index, as an index of insulin resistance, 
      were determined. RESULTS: Preterm newborns had higher HOMA, sOB-R, resistin, and 
      IL-6 and lower IGF1, IGFBP-3, leptin, and adiponectin levels than full-term 
      newborns. SGA had lower IGF1, IGFBP-3, leptin, IL-6, and adiponectin and higher 
      sOB-R and total ghrelin than AGA newborns. Adiponectin and HOMA showed 
      independent positive and negative correlations with gestational age respectively, 
      but not with neonatal weight. Birth weight was correlated positively with IGF1 
      and leptin levels and negatively with total ghrelin ones. CONCLUSIONS: Our 
      findings suggest that the lack of proper acquisition of adipose tissue by the 
      fetus either due to prematurity or to fetal growth restriction is associated with 
      changes in the cord blood adipokine profile that may contribute to the impairment 
      of glucose metabolism.
FAU - Martos-Moreno, Gabriel A
AU  - Martos-Moreno GA
AD  - Department of Endocrinology, Hospital Infantil Universitario Nino Jesus, 
      Universidad Autonoma de Madrid, E-28009 Madrid, Spain.
FAU - Barrios, Vicente
AU  - Barrios V
FAU - Saenz de Pipaon, Miguel
AU  - Saenz de Pipaon M
FAU - Pozo, Jesus
AU  - Pozo J
FAU - Dorronsoro, Izaskun
AU  - Dorronsoro I
FAU - Martinez-Biarge, Miriam
AU  - Martinez-Biarge M
FAU - Quero, Jose
AU  - Quero J
FAU - Argente, Jesus
AU  - Argente J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090626
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Adipokines)
RN  - 0 (Blood Glucose)
RN  - 0 (Ghrelin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adipokines/*blood
MH  - Blood Glucose/*metabolism
MH  - Body Weights and Measures
MH  - Cohort Studies
MH  - Female
MH  - Fetal Blood/chemistry/metabolism
MH  - Fetal Growth Retardation/*blood/epidemiology
MH  - Gestational Age
MH  - Ghrelin/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/blood
MH  - Infant, Small for Gestational Age/blood/metabolism
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Male
MH  - Premature Birth/*blood
MH  - Sex Factors
EDAT- 2009/06/30 09:00
MHDA- 2009/09/23 06:00
CRDT- 2009/06/30 09:00
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/09/23 06:00 [medline]
AID - EJE-09-0193 [pii]
AID - 10.1530/EJE-09-0193 [doi]
PST - ppublish
SO  - Eur J Endocrinol. 2009 Sep;161(3):381-9. doi: 10.1530/EJE-09-0193. Epub 2009 Jun 
      26.