PMID- 19561280
OWN - NLM
STAT- MEDLINE
DCOM- 20090807
LR  - 20220321
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 64
IP  - 7
DP  - 2009 Jul
TI  - Breast feeding, parental allergy and asthma in children followed for 8 years. The 
      PIAMA birth cohort study.
PG  - 604-9
LID - 10.1136/thx.2007.094938 [doi]
AB  - BACKGROUND: It is unclear how the association between breast feeding and asthma 
      develops with age of the child and how this association over time is influenced 
      by maternal or paternal allergy. These factors--the age of the child and maternal 
      or paternal allergy--might partly explain the conflicting results observed in 
      cross-sectional studies. METHODS: The study population consisted of 3115 Dutch 
      children born in 1996/1997 who participated in the PIAMA (Prevention and 
      Incidence of Asthma and Mite Allergy) birth cohort study. Data on breast feeding 
      and asthma (based on wheeze, dyspnoea and prescription of inhaled steroids) were 
      collected by yearly questionnaires. At 8 years, specific immunoglobulin E (IgE) 
      to airborne allergens and bronchial responsiveness were measured. Data were 
      analysed by logistic regression and generalised estimating equations (GEEs), and 
      stratified by maternal and paternal allergic status. RESULTS: 35% (n = 1081) of 
      the children were breast fed for >16 weeks. At 8 years of age, 12.6% (n = 392) 
      had asthma. Breast feeding (>16 weeks vs no breast feeding) was significantly 
      associated with a lower asthma prevalence from 3 to 8 years of age, in children 
      of both non-allergic and allergic mothers. The inverse association between breast 
      feeding and sensitisation to airborne allergens at 8 years was non-significant. 
      Breast feeding was not associated with bronchial hyper-responsiveness. No 
      interaction between breast feeding and gender, maternal allergy or paternal 
      allergy was observed in any of the associations. CONCLUSIONS: Breast feeding is 
      associated with a lower asthma risk in children until 8 years of age without 
      evidence of attenuation and regardless of the family history of allergy.
FAU - Scholtens, S
AU  - Scholtens S
AD  - Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The 
      Netherlands. salome.scholtens@rivm.nl
FAU - Wijga, A H
AU  - Wijga AH
FAU - Brunekreef, B
AU  - Brunekreef B
FAU - Kerkhof, M
AU  - Kerkhof M
FAU - Hoekstra, M O
AU  - Hoekstra MO
FAU - Gerritsen, J
AU  - Gerritsen J
FAU - Aalberse, R
AU  - Aalberse R
FAU - de Jongste, J C
AU  - de Jongste JC
FAU - Smit, H A
AU  - Smit HA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
RN  - 0 (Allergens)
SB  - IM
CIN - Thorax. 2009 Jul;64(7):558-9. PMID: 19561276
MH  - Allergens/immunology
MH  - Asthma/epidemiology/genetics/immunology/*prevention & control
MH  - Breast Feeding/*statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/epidemiology
MH  - Incidence
MH  - Infant, Newborn
MH  - Male
MH  - Netherlands/epidemiology
MH  - Parents
MH  - Time Factors
EDAT- 2009/06/30 09:00
MHDA- 2009/08/08 09:00
CRDT- 2009/06/30 09:00
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/08/08 09:00 [medline]
AID - 64/7/604 [pii]
AID - 10.1136/thx.2007.094938 [doi]
PST - ppublish
SO  - Thorax. 2009 Jul;64(7):604-9. doi: 10.1136/thx.2007.094938.