PMID- 19562059
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0974-1208 (Print)
IS  - 1998-4766 (Electronic)
IS  - 1998-4766 (Linking)
VI  - 1
IP  - 1
DP  - 2008 Jan
TI  - HLA allele associations in idiopathic recurrent spontaneous abortion patients 
      from India.
PG  - 19-24
AB  - BACKGROUND: Rejection of semiallogenic foetus in recurrent spontaneous abortion 
      (RSA) has been postulated to be a consequence of genetic and immunological 
      phenomena. AIM: To evaluate the role of human leukocyte antigen (HLA) alleles in 
      RSA in Indian couples. SETTINGS AND DESIGN: A case-control study. MATERIALS AND 
      METHODS: Eighty-one randomly selected couples with unexplained three or more RSAs 
      and a control group of 97 couples with live birth belonging to the same ethnic 
      background, referred to the Gynaecology Department, KEM Hospital were included in 
      the case-control study. Serological HLA A and B typing was done followed by 
      molecular subtypes, defined using PCR-SSOP technique for HLA A, B, and C in 40 
      couples and DRB1* and DQB1* in 28 couples which were then compared with 
      appropriate case 46 and 88 controls. RESULTS: Serologically A3 (15.43% vs. 4.43%; 
      odds ratio (OR) = 4.34; P = 0.0002) and B17 (25.3% vs. 11.34%; OR = 3.49; P = 
      0.0001) were increased. Haplotype A1-B17 was significantly increased. Molecular 
      subtyping revealed that A*030102 (11.25% vs. 4.34%; OR = 3.00; P = 0.07), B*5701 
      (11.25% vs. 1.08%; OR = 13.10; P = 0.003), Cw*120201 (25% vs. 4.34%; OR = 10.50; 
      P = 2.05E-05), HLA DRB1*030101 (17.85% vs. 3.40%; OR = 7.6; P = 0.0001), 
      DRB1*150101 (32.14% vs. 13.63%; OR = 4.8; P = 0.0003), and DQB1*060101 (35.71% 
      vs. 29.34%; OR = 2.3; P = 0.004) were significantly increased in patients. A 
      differential association was noticed when compared with reported world RSA 
      patients. CONCLUSION: The HLA alleles A*030101, B*5701, Cw*120201, DRB1*030101, 
      and DRB1*150101 as well as their associated ancestral haplotype may play a 
      significant role in development of RSA in India.
FAU - U, Shankarkumar
AU  - U S
AD  - HLA Department, Institute of Immunohaematology, 13 Floor, KEM Hospital, Parel, 
      Mumbai - 400 012, Maharashtra, India.
FAU - A, Pawar
AU  - A P
FAU - P, Gaonkar
AU  - P G
FAU - D, Parasannavar
AU  - D P
FAU - V, Salvi
AU  - V S
FAU - K, Ghosh
AU  - K G
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Hum Reprod Sci
JT  - Journal of human reproductive sciences
JID - 101473512
PMC - PMC2700679
OTO - NOTNLM
OT  - Cw*120201
OT  - DQB1*050301 association
OT  - HLA B*5701
OT  - India
OT  - RSA
COIS- Conflict of Interest: None declared.
EDAT- 2008/01/01 00:00
MHDA- 2008/01/01 00:01
PMCR- 2008/01/01
CRDT- 2009/06/30 09:00
PHST- 2007/08/09 00:00 [received]
PHST- 2008/01/25 00:00 [revised]
PHST- 2008/01/31 00:00 [accepted]
PHST- 2009/06/30 09:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2008/01/01 00:01 [medline]
PHST- 2008/01/01 00:00 [pmc-release]
AID - JHRS-01-19 [pii]
AID - 10.4103/0974-1208.39592 [doi]
PST - ppublish
SO  - J Hum Reprod Sci. 2008 Jan;1(1):19-24. doi: 10.4103/0974-1208.39592.