PMID- 19562650
OWN - NLM
STAT- MEDLINE
DCOM- 20100128
LR  - 20121115
IS  - 2040-3437 (Electronic)
IS  - 1367-6733 (Linking)
VI  - 12
IP  - 4
DP  - 2009 Jul
TI  - Small molecules targeting sodium and calcium channels for neuropathic pain.
PG  - 543-61
AB  - Neuropathic pain is a chronic disease, which impacts millions of individuals 
      worldwide. The condition is currently treated with several drugs that provide 
      pain relief that is inconsistent and complicated by CNS or cardiovascular (CV) 
      side effects. Voltage-gated sodium channels (VGSCs) and voltage-gated calcium 
      channels (VGCCs) are of particular interest as targets for neuropathic pain 
      because they control electrical signals in both the central and peripheral 
      nervous system. Recent research has demonstrated that the expression of 
      voltage-gated ion channels changes significantly under conditions of neuropathic 
      pain in rodents and humans. Selective modulation of the channels involved in the 
      pathology of the disease, while sparing the channels that are essential for 
      normal nociception, offers promising opportunities for therapeutic intervention. 
      This review summarizes recent developments of small molecules that target VGSCs 
      and VGCCs.
FAU - Bear, Brian
AU  - Bear B
AD  - Vertex Pharmaceuticals San Diego, San Diego, CA 92121, USA. 
      brian_bear@sd.vrtx.com
FAU - Asgian, Juliana
AU  - Asgian J
FAU - Termin, Andreas
AU  - Termin A
FAU - Zimmermann, Nicole
AU  - Zimmermann N
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Drug Discov Devel
JT  - Current opinion in drug discovery & development
JID - 100887519
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Calcium Channels)
RN  - 0 (NAV1.7 Voltage-Gated Sodium Channel)
RN  - 0 (NAV1.8 Voltage-Gated Sodium Channel)
RN  - 0 (SCN10A protein, human)
RN  - 0 (SCN9A protein, human)
RN  - 0 (Small Molecule Libraries)
RN  - 0 (Sodium Channel Blockers)
RN  - 0 (Sodium Channels)
SB  - IM
EIN - Curr Opin Drug Discov Devel.2009 Sep;12(5):705
MH  - Animals
MH  - Calcium Channel Blockers/chemistry/*pharmacology/therapeutic use
MH  - Calcium Channels/metabolism
MH  - Humans
MH  - Molecular Structure
MH  - NAV1.7 Voltage-Gated Sodium Channel
MH  - NAV1.8 Voltage-Gated Sodium Channel
MH  - Neuralgia/drug therapy/metabolism
MH  - Pain/*drug therapy/metabolism
MH  - Peripheral Nervous System Diseases/*drug therapy/metabolism
MH  - Small Molecule Libraries/chemistry/*pharmacology/therapeutic use
MH  - Sodium Channel Blockers/chemistry/*pharmacology/therapeutic use
MH  - Sodium Channels/metabolism
RF  - 85
EDAT- 2009/06/30 09:00
MHDA- 2010/01/29 06:00
CRDT- 2009/06/30 09:00
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2010/01/29 06:00 [medline]
PST - ppublish
SO  - Curr Opin Drug Discov Devel. 2009 Jul;12(4):543-61.