PMID- 19562702
OWN - NLM
STAT- MEDLINE
DCOM- 20090910
LR  - 20090706
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 15
IP  - 7
DP  - 2009 Jul
TI  - Quantification of liver perfusion by dynamic magnetic resonance imaging: 
      experimental evaluation and clinical pilot study.
PG  - 693-700
LID - 10.1002/lt.21746 [doi]
AB  - Changes in liver microcirculation are considered essential in assessing 
      ischemia-reperfusion injury, which in turn has an impact on liver graft function 
      and outcome following liver transplantation (LTx). The aim of this study was to 
      introduce dynamic magnetic resonance imaging (dMRI) as a new technique for 
      overall quantification of hepatic microcirculation and compare it to perfusion 
      measured by laser Doppler flowmetry (LDF; hepatic artery/portal vein) and thermal 
      diffusion (TD). The study included 3 groups, measuring hepatic blood flow and 
      microcirculation with the help of TD, LDF, and dMRI. In group I (9 landrace pigs; 
      26 +/- 5 kg), the native liver before and after partial portal occlusion was 
      studied; in group II (6 landrace pigs; 25.5 +/- 4.4 kg), the liver 24 hours after 
      LTx was studied; and in group III (14 patients), the liver on days 4 to 7 
      following LTx was studied. A close correlation was found between dMRI 
      measurements and TD (r = 0.7-0.9, P < 0.01) in 4 defined regions of interest. 
      Portal blood flow and partial occlusion of the portal vein were accurately 
      detected by LDF flowmetry and correlated well with dMRI (r = 0.95, P < 0.01). In 
      the clinical setting, representative TD measurements in segment 4b of the 
      transplanted liver correlated well with dMRI analysis in other segments. 
      Quantification of the portal blood flow and imaging of the whole liver could be 
      performed simultaneously by dMRI. In conclusion, dMRI has been proved to be a 
      sensitive modality for the quantification of liver microcirculation and hepatic 
      blood flow in experimental and clinical LTx. It allows for a synchronous, 
      noninvasive assessment of macrocirculation and microcirculation of the liver and 
      could become a valuable diagnostic tool in advanced liver surgery and 
      transplantation.
FAU - Zapletal, Christina
AU  - Zapletal C
AD  - Department of General, Visceral, and Transplantation Surgery, University of 
      Heidelberg, Heidelberg, Germany.
FAU - Jahnke, Cosima
AU  - Jahnke C
FAU - Mehrabi, Arianeb
AU  - Mehrabi A
FAU - Hess, Thomas
AU  - Hess T
FAU - Mihm, David
AU  - Mihm D
FAU - Angelescu, Michaela
AU  - Angelescu M
FAU - Stegen, Peter
AU  - Stegen P
FAU - Fonouni, Hamidreza
AU  - Fonouni H
FAU - Esmaeilzadeh, Majid
AU  - Esmaeilzadeh M
FAU - Gebhard, Martha Maria
AU  - Gebhard MM
FAU - Klar, Ernst
AU  - Klar E
FAU - Golling, Markus
AU  - Golling M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
SB  - IM
MH  - Adult
MH  - Animals
MH  - Female
MH  - Humans
MH  - Laser-Doppler Flowmetry
MH  - Liver/blood supply/*pathology
MH  - Liver Transplantation/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Microcirculation
MH  - Middle Aged
MH  - Perfusion
MH  - Pilot Projects
MH  - Swine
MH  - Treatment Outcome
EDAT- 2009/06/30 09:00
MHDA- 2009/09/11 06:00
CRDT- 2009/06/30 09:00
PHST- 2009/06/30 09:00 [entrez]
PHST- 2009/06/30 09:00 [pubmed]
PHST- 2009/09/11 06:00 [medline]
AID - 10.1002/lt.21746 [doi]
PST - ppublish
SO  - Liver Transpl. 2009 Jul;15(7):693-700. doi: 10.1002/lt.21746.