PMID- 19563016
OWN - NLM
STAT- MEDLINE
DCOM- 20100527
LR  - 20090630
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 30
IP  - 2
DP  - 2009 Feb
TI  - [Non-T-cell depleted HLA haploidentical peripheral blood stem cell 
      transplantation for hematological malignancies: report of 36 cases].
PG  - 82-6
AB  - OBJECTIVE: To analyze the clinical outcome of human leukocyte antigen (HLA) 
      haploidentical peripheral blood stem cell transplantation (PBSCT) from related 
      donors for hematological malignancies. METHODS: Thirty-six patients with 
      hematological malignancies, with a median age of 25 (11-48) years, were 
      transplanted with PBSC from an HLA-haploidentical family donors: 7 were 1 locus 
      mismatched and 29 were 2-3 loci mismatched. The recipients received myeloablative 
      conditioning regimen, in combination with different immunosuppressants according 
      to the degree of HLA disparity followed by non-T-cell depleted PBSCT. The median 
      number of CD34+ cells were 11 (4.16-21.00) x 10(6)/kg. RESULTS: All patients 
      achieved sustained, full donor-type engraftment. Fifteen patients (41.7%) 
      developed grade I-II aGVHD. Among 29 patients followed up more than 18 months, 17 
      (58.6%) developed cGVHD. There was no statistical difference in decrease and 
      recovery of T, B and NK cell subsets after transplantation between HLA 
      haploidentical group and HLA identical PBSCT group. The median follow-up duration 
      was 15 (4 -69) months. Five patients (13.9% ) relapsed. The 2-year probability of 
      leukemia-free survival (LFS) was 82.2%. CONCLUSION: Non-T-cell depleted 
      HLA-haploidentical PBSCT is safe and feasible for patients with hematological 
      malignancies after myeloablative conditioning regimen combined with intensive 
      immunosuppressants.
FAU - Yuan, Hai-long
AU  - Yuan HL
AD  - Department of Hematology, First Affiliated Hospital, Xinjiang Medical University, 
      Urumqi 830054, China.
FAU - Li, Ling
AU  - Li L
FAU - Qu, Jian-hua
AU  - Qu JH
FAU - Wen, Bing-zhao
AU  - Wen BZ
FAU - Jiang, Ming
AU  - Jiang M
FAU - Hao, Jian-ping
AU  - Hao JP
FAU - Chen, Rong
AU  - Chen R
FAU - Guo, Xin-hong
AU  - Guo XH
FAU - Halida, Yasen
AU  - Halida Y
FAU - Wang, Shan-zheng
AU  - Wang SZ
FAU - Ding, Ling-lu
AU  - Ding LL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/prevention & control
MH  - HLA Antigens/genetics/immunology
MH  - Haploidy
MH  - Hematologic Neoplasms/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Peripheral Blood Stem Cell Transplantation
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/07/01 09:00
MHDA- 2010/05/28 06:00
CRDT- 2009/07/01 09:00
PHST- 2009/07/01 09:00 [entrez]
PHST- 2009/07/01 09:00 [pubmed]
PHST- 2010/05/28 06:00 [medline]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):82-6.