PMID- 19563766
OWN - NLM
STAT- MEDLINE
DCOM- 20091102
LR  - 20211020
IS  - 1096-0309 (Electronic)
IS  - 0003-2697 (Print)
IS  - 0003-2697 (Linking)
VI  - 394
IP  - 1
DP  - 2009 Nov 1
TI  - Identification of heme propionate vibrational modes in the resonance Raman 
      spectra of cytochrome c oxidase.
PG  - 141-3
LID - 10.1016/j.ab.2009.06.035 [doi]
AB  - The propionate groups of heme a and a(3) in cytochrome c oxidase (CcO) have been 
      postulated to mediate both the electron and proton transfer within the enzyme. To 
      establish structural markers for the propionate groups, their associated 
      vibrational modes were identified in the resonance Raman spectra of CcO from 
      bovine (bCcO) and Rhodobacter sphaeroides (RsCcO). The distinction between the 
      modes from the propionates of heme a and heme a(3), as well as those from the 
      propionates on the pyrrole rings A and D in each heme, was made on the basis of 
      H2O-D2O isotope substitution experiments combined with wavelength-selective 
      resonance enhancement (for bCcO) or mutagenesis studies (for RsCcO).
FAU - Egawa, Tsuyoshi
AU  - Egawa T
AD  - Department of Physiology and Biophysics, Albert Einstein College of Medicine, 
      Bronx, NY 10461, USA.
FAU - Lee, Hyun Ju
AU  - Lee HJ
FAU - Ji, Hong
AU  - Ji H
FAU - Gennis, Robert B
AU  - Gennis RB
FAU - Yeh, Syun-Ru
AU  - Yeh SR
FAU - Rousseau, Denis L
AU  - Rousseau DL
LA  - eng
GR  - R01 GM074982/GM/NIGMS NIH HHS/United States
GR  - R01 HL016101/HL/NHLBI NIH HHS/United States
GR  - HL016101/HL/NHLBI NIH HHS/United States
GR  - R37 HL016101/HL/NHLBI NIH HHS/United States
GR  - GM074982/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090627
PL  - United States
TA  - Anal Biochem
JT  - Analytical biochemistry
JID - 0370535
RN  - 0 (Propionates)
RN  - 42VZT0U6YR (Heme)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Crystallography, X-Ray
MH  - Electron Transport Complex IV/*chemistry
MH  - Heme/*chemistry
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Propionates/*chemistry
MH  - Rhodobacter sphaeroides/enzymology
MH  - Spectrum Analysis, Raman
MH  - *Vibration
PMC - PMC3418657
MID - NIHMS138983
EDAT- 2009/07/01 09:00
MHDA- 2009/11/03 06:00
PMCR- 2012/08/14
CRDT- 2009/07/01 09:00
PHST- 2009/04/22 00:00 [received]
PHST- 2009/06/24 00:00 [accepted]
PHST- 2009/07/01 09:00 [entrez]
PHST- 2009/07/01 09:00 [pubmed]
PHST- 2009/11/03 06:00 [medline]
PHST- 2012/08/14 00:00 [pmc-release]
AID - S0003-2697(09)00456-4 [pii]
AID - 10.1016/j.ab.2009.06.035 [doi]
PST - ppublish
SO  - Anal Biochem. 2009 Nov 1;394(1):141-3. doi: 10.1016/j.ab.2009.06.035. Epub 2009 
      Jun 27.