PMID- 19564714
OWN - NLM
STAT- MEDLINE
DCOM- 20091109
LR  - 20191111
IS  - 1349-7413 (Electronic)
IS  - 0911-4300 (Linking)
VI  - 32
IP  - 3
DP  - 2009 Jun
TI  - Elevation of plasma eotaxin levels in children with food allergy.
PG  - 180-5
AB  - BACKGROUND: Eosinophils play an important role in allergic responses. Eotaxin is 
      a CC chemokine that promotes the selective recruitment of eosinophils. This study 
      was performed to investigate the significance of eotaxin in pediatric food 
      allergies. METHODS: The study population included 35 patients with food allergy, 
      18 patients with atopic dermatitis but without food allergy, and 19 age-matched 
      non-allergic controls. Eotaxin-1 and eotaxin-3 levels in plasma were assayed by 
      enzyme-linked immunosorbent assay. Simultaneously, eosinophil counts in 
      peripheral blood and serum immunoglobulin E (IgE) values were assessed. RESULTS: 
      Plasma eotaxin-1 levels were 93.6+/-33.4 pg/ml in patients with food allergy, 
      78.0+/-31.8 pg/ml in patients with atopic dermatitis, and 60.4+/-15.7 pg/ml in 
      controls. Differences between the food allergy and control groups were 
      significant (P<0.001). Circulating eosinophil counts in patients with food 
      allergy were higher than those in controls (5.84+/-9.46x10(9)/l vs. 
      1.20+/-1.11x10(9)/l, P<0.001). Nevertheless, eotaxin-1 levels in children with 
      food allergy were not correlated with eosinophil counts or serum IgE levels. 
      There were no significant differences in eotaxin-3 levels between the 3 groups. 
      CONCLUSION: Plasma levels of eotaxin-1 were elevated in children with food 
      allergy. The pathophysiological relevance of the increase in eotaxin is 
      discussed.
FAU - Matsuura, Hiroki
AU  - Matsuura H
AD  - Department of Pediatrics, Mizonokuchi Hospital, Teikyo University School of 
      Medicine, Kawasaki, Japan.
FAU - Ishiguro, Akira
AU  - Ishiguro A
FAU - Abe, Hiroyuki
AU  - Abe H
FAU - Mamada, Yoko
AU  - Mamada Y
FAU - Suzuki, Tetsuomi
AU  - Suzuki T
FAU - Kohda, Kyoko
AU  - Kohda K
FAU - Shimbo, Toshikazu
AU  - Shimbo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Nihon Rinsho Meneki Gakkai Kaishi
JT  - Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
JID - 9505992
RN  - 0 (Chemokine CCL11)
SB  - IM
MH  - Chemokine CCL11/*blood
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/blood
MH  - Food Hypersensitivity/*blood
MH  - Humans
MH  - Infant
EDAT- 2009/07/01 09:00
MHDA- 2009/11/10 06:00
CRDT- 2009/07/01 09:00
PHST- 2009/07/01 09:00 [entrez]
PHST- 2009/07/01 09:00 [pubmed]
PHST- 2009/11/10 06:00 [medline]
AID - JST.JSTAGE/jsci/32.180 [pii]
AID - 10.2177/jsci.32.180 [doi]
PST - ppublish
SO  - Nihon Rinsho Meneki Gakkai Kaishi. 2009 Jun;32(3):180-5. doi: 
      10.2177/jsci.32.180.