PMID- 19564826
OWN - NLM
STAT- MEDLINE
DCOM- 20090902
LR  - 20221207
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Linking)
VI  - 15
IP  - 7
DP  - 2009 Jul
TI  - Primary lung cancer and TNF-alpha gene polymorphisms: a case-control study in a 
      Croatian population.
PG  - CR361-5
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine 
      involved in the pathogenesis of various inflammatory and malignant diseases. 
      Previous studies investigating the role of the TNF-alpha gene polymorphisms in 
      lung cancer have generated contradictory results. The present study investigated 
      whether the TNF-alpha-308 and TNF-alpha-238 polymorphisms are associated with 
      risk and/or severity of disease in Croatian lung cancer patients. This is the 
      first study in a Caucasian population to analyze the influence of these two 
      polymorphisms on multiple types of lung cancer. MATERIAL/METHODS: In a 
      case-control study, lung cancer patients (n=230) and appropriate age- and 
      sex-matched controls (n=230) were genotyped by the polymerase chain 
      reaction/restriction fragment length polymorphism method. Allele and genotype 
      frequencies were estimated by gene counting. The chi-squared test was used to 
      compare the observed numbers of different TNF-alpha genotypes for the population 
      with those predicted by Hardy-Weinberg equilibrium. Differences in genotype and 
      allele distributions in the patient and control groups were analyzed for 
      statistical significance using the chi-squared test or Fisher's exact test as 
      appropriate. RESULTS: There were no significant differences in the genotype and 
      allele frequencies for the TNF-alpha-308 and TNF-alpha-238 polymorphisms between 
      lung cancer patients and controls. Furthermore, no association between the 
      genotypes and different stages of lung cancer was detected. CONCLUSIONS: This 
      study indicates that the TNF-alpha-308 and TNF-alpha-238 polymorphisms do not 
      influence susceptibility to or severity of lung cancer in a Croatian population.
FAU - Flego, Veljko
AU  - Flego V
AD  - Department of Pulmonology, Clinical Hospital Center Rijeka, Rijeka, Croatia. 
      veljko.fl ego2@ri.t-com.hr
FAU - Radojcic Badovinac, Andjelka
AU  - Radojcic Badovinac A
FAU - Bulat-Kardum, Ljiljana
AU  - Bulat-Kardum L
FAU - Matanic, Dubravka
AU  - Matanic D
FAU - Crnic-Martinovic, Marija
AU  - Crnic-Martinovic M
FAU - Kapovic, Miljenko
AU  - Kapovic M
FAU - Ristic, Smiljana
AU  - Ristic S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Croatia
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Lung Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People/*genetics
EDAT- 2009/07/01 09:00
MHDA- 2009/09/03 06:00
CRDT- 2009/07/01 09:00
PHST- 2009/07/01 09:00 [entrez]
PHST- 2009/07/01 09:00 [pubmed]
PHST- 2009/09/03 06:00 [medline]
AID - 869711 [pii]
PST - ppublish
SO  - Med Sci Monit. 2009 Jul;15(7):CR361-5.