PMID- 19565402
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20151119
IS  - 1747-7174 (Electronic)
IS  - 1747-7166 (Linking)
VI  - 5
IP  - 1
DP  - 2010
TI  - Is obesity associated with oxidative stress in children?
PG  - 56-63
LID - 10.3109/17477160903055945 [doi]
AB  - OBJECTIVE: We evaluated the presence of oxidative stress in obese children 
      without co-morbidities. METHODS: The study population included 68 children (30 
      girls, 38 boys), between 6 and 14 years of age. The levels of markers of 
      oxidative damage (malondialdehyde [MDA], and plasma carbonyl groups [CG]) and 
      measures of antioxidant defense, such as the enzyme glutathione peroxidase (GPx) 
      and low molecular scavengers (erythrocyte-reduced glutathione [GSH], 
      alpha-tocopherol and beta-carotene) were determined. Children were categorized in 
      groups by the standard deviation score of body mass index (SDS-BMI). Twenty 
      children were non-obese (SDS-BMI< or =1.33), and the 48 obese children (SDS-BMI> 
      or =2) were further divided into two groups: SDS-BMI> or =3 (22 children) and > 
      or =2 SDS-BMI<3 (26 children). RESULTS: The levels of MDA and CG were 
      significantly higher (p<0.05) in children with SDS-BMI> or =3. The GPx activity 
      was increased, while the GSH concentration was lower in obese children compared 
      with non-obese children (p<0.01). There were no differences in serum 
      alpha-tocopherol and beta-carotene levels between groups. MDA was the sole marker 
      of oxidative damage that was positively correlated with SDS-BMI, (r=0.35, 
      p=0.015), and negatively with high-density lipoprotein cholesterol (HDL-C) (r=- 
      0.32, p=0.027). GPx was inversely related to total cholesterol (r=- 0.34, 
      p=0.019). In multiple regression analysis, we confirmed that SDS-BMI and HDL-C 
      were determinants of MDA. CONCLUSIONS: Severe childhood obesity is associated 
      with oxidative stress. Thus, providing foods with high antioxidant capacity in 
      addition to a hypocaloric diet is crucial for the treatment of obese children.
FAU - Codoner-Franch, Pilar
AU  - Codoner-Franch P
AD  - Department of Pediatrics, Dr Peset University Hospital, Valencia, Spain. 
      pilar.codoner@uv.es
FAU - Boix-Garcia, Laura
AU  - Boix-Garcia L
FAU - Simo-Jorda, Raquel
AU  - Simo-Jorda R
FAU - Del Castillo-Villaescusa, Cristina
AU  - Del Castillo-Villaescusa C
FAU - Maset-Maldonado, Jesus
AU  - Maset-Maldonado J
FAU - Valls-Belles, Victoria
AU  - Valls-Belles V
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Pediatr Obes
JT  - International journal of pediatric obesity : IJPO : an official journal of the 
      International Association for the Study of Obesity
JID - 101256330
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 01YAE03M7J (beta Carotene)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - GAN16C9B8O (Glutathione)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Adolescent
MH  - Antioxidants/*metabolism
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Child
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glutathione/blood
MH  - Glutathione Peroxidase/blood
MH  - Humans
MH  - Male
MH  - Malondialdehyde/blood
MH  - Obesity/*blood/physiopathology
MH  - *Oxidative Stress
MH  - Prospective Studies
MH  - Protein Carbonylation
MH  - Spain
MH  - alpha-Tocopherol/blood
MH  - beta Carotene/blood
EDAT- 2009/07/01 09:00
MHDA- 2010/07/07 06:00
CRDT- 2009/07/01 09:00
PHST- 2009/07/01 09:00 [entrez]
PHST- 2009/07/01 09:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 912780751 [pii]
AID - 10.3109/17477160903055945 [doi]
PST - ppublish
SO  - Int J Pediatr Obes. 2010;5(1):56-63. doi: 10.3109/17477160903055945.