PMID- 19568005
OWN - NLM
STAT- MEDLINE
DCOM- 20100114
LR  - 20211203
IS  - 1473-6322 (Electronic)
IS  - 1473-6322 (Linking)
VI  - 9
IP  - 4
DP  - 2009 Aug
TI  - The role of immunoglobulin E-binding epitopes in the characterization of food 
      allergy.
PG  - 357-63
LID - 10.1097/ACI.0b013e32832d05ba [doi]
AB  - PURPOSE OF REVIEW: Allergen-specific immunoglobulin E (IgE) antibodies play a 
      central role in food allergic reactions. IgE epitope mapping of food allergens 
      may provide information regarding patient's clinical history and contribute to 
      food allergy diagnosis/prognosis. The goal of this article is to review recent 
      developments in the methods for IgE epitope mapping and the role of IgE-binding 
      epitopes in the characterization of food allergy. RECENT FINDINGS: Recent studies 
      have suggested a potential role for sequential IgE-binding epitopes as biomarkers 
      for characterizing various phenotypes of food allergy. Studies of allergens in 
      milk, peanut, egg and wheat have shown a correlation between IgE sequential 
      epitope diversity and patients' allergy severity or persistence. Several 
      informative epitopes in milk allergens have been identified as candidate 
      biomarkers to predict the development of tolerance to milk. However, limitations 
      with current methods of IgE-binding epitope identification need to be addressed 
      before they can be applied in the diagnosis/prognosis of food allergy. SUMMARY: 
      IgE epitope mapping has the potential to become an additional tool for the 
      diagnosis/prognosis of food allergy and lead to a better understanding of the 
      pathogenesis and tolerance induction of food allergy.
FAU - Lin, Jing
AU  - Lin J
AD  - Department of Pediatric Allergy and Immunology, Jaffe Food Allergy Research 
      Institute, Mount Sinai School of Medicine, New York, New York 10029-6574, USA.
FAU - Sampson, Hugh A
AU  - Sampson HA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Allergy Clin Immunol
JT  - Current opinion in allergy and clinical immunology
JID - 100936359
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 0 (Epitopes, B-Lymphocyte)
RN  - 0 (Peptide Fragments)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/chemistry/immunology/*metabolism
MH  - Antibody Diversity/immunology
MH  - Biomarkers/metabolism
MH  - Diagnostic Errors
MH  - Disease Progression
MH  - Epitope Mapping/*methods/statistics & numerical data
MH  - Epitopes, B-Lymphocyte/chemistry/*immunology/metabolism
MH  - Food/adverse effects
MH  - Food Hypersensitivity/diagnosis/*immunology/physiopathology
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Immunosuppression Therapy/trends
MH  - Peptide Fragments/chemistry/*immunology/metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
RF  - 45
EDAT- 2009/07/02 09:00
MHDA- 2010/01/15 06:00
CRDT- 2009/07/02 09:00
PHST- 2009/07/02 09:00 [entrez]
PHST- 2009/07/02 09:00 [pubmed]
PHST- 2010/01/15 06:00 [medline]
AID - 00130832-200908000-00014 [pii]
AID - 10.1097/ACI.0b013e32832d05ba [doi]
PST - ppublish
SO  - Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):357-63. doi: 
      10.1097/ACI.0b013e32832d05ba.