PMID- 19568708
OWN - NLM
STAT- MEDLINE
DCOM- 20090731
LR  - 20211020
IS  - 1672-0415 (Print)
IS  - 1672-0415 (Linking)
VI  - 15
IP  - 3
DP  - 2009 Jun
TI  - Study on the relationship between blood stasis syndrome and clinical pathology in 
      227 patients with primary glomerular disease.
PG  - 170-6
LID - 10.1007/s11655-009-0170-4 [doi]
AB  - OBJECTIVE: To investigate the relationship between the severity of Chinese 
      medicine (CM) blood stasis syndrome (BSS) with clinical features and renal lesion 
      indexes of the primary glomerular disease. METHODS: An epidemiological survey was 
      conducted to collect the data of 227 patients diagnosed as chronic primary 
      glomerular diseases, and their severity of BSS were scored three days before 
      renal biopsies were performed. The following clinical indexes were analyzed: age, 
      course of glomerular diseases, 24-h urine protein ration (Upro), hypertension and 
      blood pressure (BP) progress, serum creatinine levels (Scr), estimation of 
      glomerular filtration rate based on the predigesting equation of MDRD (eGFR), 
      blood urea nitrogen (BUN), uric acid (UA), triglyceride (TG), cholesterol (CHO), 
      haematoglobin (HGB), albumin (ALB), and the correlation among renal pathological 
      types, pathology lesion indexes, and BSS scores. RESULTS: (1) Among the 227 
      patients, 207 (91.19%) were diagnosed as BSS, in which 95 cases were considered 
      as moderate and the rest 112 cases as severe. (2) There was a negative 
      correlation between age, gender, grades of the hypertension, and the BSS score. 
      Multiple stepwise regression analysis showed that Upro, CHO, TG, and eGFR were 
      positively related to the BSS score (P<0.05). (3) The BSS score has a positive 
      correlation with indexes of chronic renal pathology, especially the tubular 
      atrophy and interstitial fibrosis. The severity of proliferation and glomerular 
      sclerosis was accompanied with higher BSS scores with a significant difference 
      (P<0.05). CONCLUSIONS: BSS is one of the most common CM syndromes among patients 
      with the primary glomerular diseases; the BSS score has a positive correlation 
      with Upro, CHO, TG, eGFR, as well as the index of chronic renal pathology. Based 
      on these observations, the BSS may be used as an indicator of the development of 
      renal diseases. Being positively diagnosed as BSS could indicate the beginning of 
      the chronic phase of the primary glomerular diseases.
FAU - Li, Shen
AU  - Li S
AD  - Department of Nephrology, Guang'anmen Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100053, China. lishen58173@163.com
FAU - Rao, Xiang-rong
AU  - Rao XR
FAU - Wang, Su-xia
AU  - Wang SX
FAU - Zhang, Gai-hua
AU  - Zhang GH
FAU - Li, Xiao-mei
AU  - Li XM
FAU - Dai, Xi-wen
AU  - Dai XW
FAU - Chen, Ke-ji
AU  - Chen KJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090702
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Circulation/*physiology
MH  - Female
MH  - Glomerulonephritis/pathology/physiopathology
MH  - Humans
MH  - Hypertension, Renal/pathology/physiopathology
MH  - *Integrative Medicine
MH  - Kidney/pathology
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Middle Aged
MH  - *Qi
MH  - Renal Insufficiency, Chronic/*pathology/*physiopathology
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2009/07/02 09:00
MHDA- 2009/08/01 09:00
CRDT- 2009/07/02 09:00
PHST- 2008/06/16 00:00 [received]
PHST- 2009/07/02 09:00 [entrez]
PHST- 2009/07/02 09:00 [pubmed]
PHST- 2009/08/01 09:00 [medline]
AID - 10.1007/s11655-009-0170-4 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2009 Jun;15(3):170-6. doi: 10.1007/s11655-009-0170-4. Epub 
      2009 Jul 2.