PMID- 19568796
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1864-6158 (Print)
IS  - 1864-6166 (Electronic)
IS  - 1864-6158 (Linking)
VI  - 1
IP  - 1-4
DP  - 2008 Nov
TI  - Rapamycin and mTOR kinase inhibitors.
PG  - 27-36
LID - 10.1007/s12154-008-0003-5 [doi]
AB  - Mammalian target of rapamycin (mTOR) is a protein kinase that controls cell 
      growth, proliferation, and survival. mTOR signaling is often upregulated in 
      cancer and there is great interest in developing drugs that target this enzyme. 
      Rapamycin and its analogs bind to a domain separate from the catalytic site to 
      block a subset of mTOR functions. These drugs are extremely selective for mTOR 
      and are already in clinical use for treating cancers, but they could potentially 
      activate an mTOR-dependent survival pathway that could lead to treatment failure. 
      By contrast, small molecules that compete with ATP in the catalytic site would 
      inhibit all of the kinase-dependent functions of mTOR without activating the 
      survival pathway. Several non-selective mTOR kinase inhibitors have been 
      described and here we review their chemical and cellular properties. Further 
      development of selective mTOR kinase inhibitors holds the promise of yielding 
      potent anticancer drugs with a novel mechanism of action.
FAU - Ballou, Lisa M
AU  - Ballou LM
AD  - Department of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
FAU - Lin, Richard Z
AU  - Lin RZ
LA  - eng
GR  - R01 DK062722/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20080515
PL  - Germany
TA  - J Chem Biol
JT  - Journal of chemical biology
JID - 101318662
PMC - PMC2698317
EDAT- 2009/07/02 09:00
MHDA- 2009/07/02 09:01
PMCR- 2009/11/01
CRDT- 2009/07/02 09:00
PHST- 2008/02/19 00:00 [received]
PHST- 2008/03/11 00:00 [accepted]
PHST- 2009/07/02 09:00 [entrez]
PHST- 2009/07/02 09:00 [pubmed]
PHST- 2009/07/02 09:01 [medline]
PHST- 2009/11/01 00:00 [pmc-release]
AID - 3 [pii]
AID - 10.1007/s12154-008-0003-5 [doi]
PST - ppublish
SO  - J Chem Biol. 2008 Nov;1(1-4):27-36. doi: 10.1007/s12154-008-0003-5. Epub 2008 May 
      15.