PMID- 19568921
OWN - NLM
STAT- MEDLINE
DCOM- 20100119
LR  - 20211020
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 32
IP  - 5
DP  - 2009 Oct
TI  - Fish oil-supplemented parenteral nutrition in severe acute pancreatitis patients 
      and effects on immune function and infectious risk: a randomized controlled 
      trial.
PG  - 304-9
LID - 10.1007/s10753-009-9136-0 [doi]
AB  - The human leukocyte antigen (HLA)-DR expression on monocytes and plasma 
      Interleukin (IL)-10 levels are key indicators of immune response during the acute 
      phase of severe acute pancreatitis (SAP). We designed a pilot study to 
      investigate whether omega-3 fatty acids (FAs) supplemented parenteral nutrition 
      (PN) could improve immune response in SAP patients. Fifty-six SAP patients were 
      enrolled (28 patients in each group) and received isocaloric and isonitrogenous 
      parenteral nutrition, providing 1.0 g/kg/day standard soybean-oil based fat 
      (omega-6 FAs group) or 0.8 g/kg/day soybean oil +0.2 g/kg/day omega-3 FAs based 
      fat (omega-3 FAs group). IL-10, HLA-DR and the ratio of CD4(+) to CD8(+) were 
      determined before PN treatment and on day 6 after starting PN. The infection and 
      surgery rates were recorded until hospital discharge. A significant IL-10 
      increase was associated with the administration of omega-3 FAs (p = 0.04, vs 
      omega-6 FAs group). Monocyte HLA-DR expression improved in both groups after 5 
      days of PN treatment. This increase was significantly higher in the omega-3 FAs 
      group compared to omega-6 FAs (p = 0.01). There was no significant difference of 
      CD4(+)/CD8(+), infection and surgery rates between the two groups. In conclusion, 
      omega-3 FAs supplemented PN can elevate the IL-10 level and HLA-DR expression in 
      SAP patients. A larger trial is required to see whether omega-3 FAs supplemented 
      PN treatment in SAP patients would result in better clinical outcomes than 
      omega-6 FAs.
FAU - Wang, Xinying
AU  - Wang X
AD  - Research Institute of General Surgery, Jinling Hospital, Medical School of 
      Nanjing University, Nanjing, China. wxinying@263.net
FAU - Li, Weiqin
AU  - Li W
FAU - Zhang, Feng
AU  - Zhang F
FAU - Pan, Liya
AU  - Pan L
FAU - Li, Ning
AU  - Li N
FAU - Li, Jieshou
AU  - Li J
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Omega-6)
RN  - 0 (Fish Oils)
RN  - 130068-27-8 (Interleukin-10)
RN  - 8001-22-7 (Soybean Oil)
SB  - IM
MH  - APACHE
MH  - Acute Disease
MH  - Adult
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Enteral Nutrition/methods
MH  - Fatty Acids, Omega-3/*administration & dosage
MH  - Fatty Acids, Omega-6/administration & dosage
MH  - Female
MH  - Fish Oils/*administration & dosage
MH  - Humans
MH  - Immune System/*drug effects/metabolism
MH  - Infections/therapy
MH  - Interleukin-10/biosynthesis/blood
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/therapy
MH  - Parenteral Nutrition/*methods
MH  - Pilot Projects
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Soybean Oil/administration & dosage
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2009/07/02 09:00
MHDA- 2010/01/20 06:00
CRDT- 2009/07/02 09:00
PHST- 2009/07/02 09:00 [entrez]
PHST- 2009/07/02 09:00 [pubmed]
PHST- 2010/01/20 06:00 [medline]
AID - 10.1007/s10753-009-9136-0 [doi]
PST - ppublish
SO  - Inflammation. 2009 Oct;32(5):304-9. doi: 10.1007/s10753-009-9136-0.