PMID- 19569069
OWN - NLM
STAT- MEDLINE
DCOM- 20100301
LR  - 20211020
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 32
IP  - 6
DP  - 2009 Jun
TI  - Metabolic syndrome increases mortality in heart failure.
PG  - 327-31
LID - 10.1002/clc.20496 [doi]
AB  - BACKGROUND: Metabolic syndrome (MetS) is a risk factor for diabetes, 
      cardiovascular disease, and heart failure, but little is known about the impact 
      of MetS in patients who already have heart failure (HF). HYPOTHESIS: MetS 
      increases mortality in HF. METHODS: We performed an analysis in 865 indigent HF 
      patients enrolled in a HF disease management program at the Chabert Medical 
      Center in Louisiana. All subjects were classified as having MetS if they met 
      three or more of the National Cholesterol Education Program criteria. Mortality 
      was defined using the Social Security Death Index. We calculated the relative 
      hazard (RH) of death for those patients with and without MetS. RESULTS: The 
      prevalence of MetS was 40% (95% confidence interval [CI]: 37-43). These subjects 
      had similar ages (54.3+/-13.4 vs 55.7+/-12.8 years), more likely to be female 
      (43% vs 33%), had similar baseline ejection fraction (31.4+/-9.7 vs 30.0+/-11.0), 
      and New York Heart Association (NYHA) classification (2.20+/-0.9 vs 2.15+/-0.9). 
      After 2.6+/-2.2 years of follow-up 24% of the MetS group died compared to 16% in 
      the non-MetS group (p < 0.01). The RH of death for the MetS group was 1.5 (95% 
      CI: 1.1-2.1) when compared to the non-MetS group after adjustment demographics, 
      use of angiotensin-converting enzyme (ACE) inhibitor and beta-blocker, 
      hematocrit, creatinine, educational level, and baseline ejection fraction. 
      CONCLUSIONS: The prevalence of MetS is high in indigent HF patients, and it 
      increases the risk of death. Physicians treating patients with HF need to address 
      the current MetS epidemic in HF.
CI  - 2009 Wiley Periodicals, Inc.
FAU - Tamariz, Leonardo
AU  - Tamariz L
AD  - Department of Medicine, Miller School of Medicine at the University of Miami, 
      Miami, Florida 33136, USA. ltamariz@med.miami.edu
FAU - Hassan, Benjamin
AU  - Hassan B
FAU - Palacio, Ana
AU  - Palacio A
FAU - Arcement, Lee
AU  - Arcement L
FAU - Horswell, Ron
AU  - Horswell R
FAU - Hebert, Kathy
AU  - Hebert K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heart Failure/diagnostic imaging/*mortality/physiopathology/therapy
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Louisiana/epidemiology
MH  - Male
MH  - Metabolic Syndrome/diagnosis/*mortality
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prevalence
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ultrasonography
MH  - Ventricular Function, Left
PMC - PMC6653189
EDAT- 2009/07/02 09:00
MHDA- 2010/03/02 06:00
PMCR- 2009/06/30
CRDT- 2009/07/02 09:00
PHST- 2009/07/02 09:00 [entrez]
PHST- 2009/07/02 09:00 [pubmed]
PHST- 2010/03/02 06:00 [medline]
PHST- 2009/06/30 00:00 [pmc-release]
AID - CLC20496 [pii]
AID - 10.1002/clc.20496 [doi]
PST - ppublish
SO  - Clin Cardiol. 2009 Jun;32(6):327-31. doi: 10.1002/clc.20496.