PMID- 19571488
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20190911
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 34 Suppl 2
DP  - 2009
TI  - Children's immunology, what can we learn from animal studies (1): Decidual cells 
      induce specific immune system of feto-maternal interface.
PG  - SP331-9
AB  - In mammals, pregnancy has very interesting interaction between the maternal 
      uterus and the fetus. For maternal immune system, fetus is recognized as 
      semiallograft. However the maternal immune cells do not attack and reject a fetus 
      during a pregnant period. The reason why that immune tolerance is established in 
      the maternal decidua is the specific area defined as the feto-maternal interface. 
      While, if maternal immune cells recognize fetus as the not-self, the maternal 
      immune cells will try to reject fetus, and then abortion will occur. For example, 
      in a human, one of the reasons why the habitual abortion is understood as the 
      failure of the maternal immune system. The extravillous cytotrophoblast are not 
      attacked by the maternal immune cells, although that trophoblasts might reach 
      even the myometrium. Exceeding the maternal myometrium doesn't decide the 
      invasion of extravillous cytotrophoblast on the other hand. This suggests that 
      proliferation in decidua be strictly adjusted. In human and mice, the maternal 
      immune cells recognize the fetus trophoblasts. To escape from attack of 
      lymphocytes, villous trophoblasts do not express classical major 
      histocompatibility complex (MHC) class I molecules. But, in a human, extravillous 
      trophoblasts express MHC-class I molecules such as human leukocyte antigen 
      (HLA)-C, HLA-E and HLA-G, which are specific ligands for uterine NK (uNK) cells. 
      In the decidua, various lymphocytes including T-cells, Tregs, macrophages, and 
      uNK cells exist. Each immunocytes are not identified on their function, compose 
      network with the decidual cells under progesterone existence, and interact with 
      the success of pregnancy.
FAU - Nakamura, Orie
AU  - Nakamura O
AD  - Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, 
      Japan. nakamura@mch.pref.osaka.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Decidua/*cytology/*immunology
MH  - Female
MH  - Fetus/*immunology
MH  - Humans
MH  - Immune System/*immunology
MH  - Immune Tolerance
MH  - Insulin-Like Growth Factor I
MH  - Killer Cells, Natural/immunology
MH  - Macrophages/immunology
MH  - Maternal-Fetal Exchange/*immunology
MH  - Mice
MH  - Pregnancy/*immunology
MH  - T-Lymphocytes/immunology
MH  - Trophoblasts/cytology/immunology
MH  - Uterus/cytology/immunology
RF  - 30
EDAT- 2009/07/03 09:00
MHDA- 2009/09/22 06:00
CRDT- 2009/07/03 09:00
PHST- 2009/07/03 09:00 [entrez]
PHST- 2009/07/03 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - JST.JSTAGE/jts/34.SP331 [pii]
AID - 10.2131/jts.34.sp331 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2009;34 Suppl 2:SP331-9. doi: 10.2131/jts.34.sp331.