PMID- 19572707
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20100326
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 81
IP  - 15
DP  - 2009 Aug 1
TI  - Nonbiological inhibition-based sensing (NIBS) demonstrated for the detection of 
      toxic sulfides.
PG  - 6416-21
LID - 10.1021/ac9009353 [doi]
AB  - The purpose of this paper is to report on a new technique in chemical detection: 
      nonbiological inhibition-based sensing (NIBS). This method uses a new approach to 
      chemical amplification, where the analyte inhibits rather than enhances the rate 
      of catalytic reaction. Although there are many possible catalysts for this 
      technique, such as enzymes, this paper focuses on using the selective binding 
      found in colorimetric detection. Colorimetric methods are selective; however, 
      they are not particularly sensitive. Using nonbiological-based molecules allows 
      for selective detection without the shelf-life issues that are associated with 
      enzymes. In practice, we can use the active substances in Draeger tubes and 
      related systems as catalysts. Analytes of interest inhibit the catalysts that 
      leads to a large signal. The work presented here focuses on the detection of 
      toxic sulfide compounds. Using NIBS, we observe that we can enhance the 
      sensitivity of the system by 2 orders of magnitude with no apparent loss in 
      selectivity. We can also decrease the detection time from 5 h to 10 min. So far, 
      we have demonstrated the technique for sulfide detection; however, we believe 
      that the technique can have general use in the detection of toxic compounds.
FAU - Monty, Chelsea N
AU  - Monty CN
AD  - Department of Chemical and Biomolecular Engineering, University of Illinois at 
      Urbana-Champaign, Urbana, Illinois 61801, USA.
FAU - Londono, Nicolas J
AU  - Londono NJ
FAU - Masel, Richard I
AU  - Masel RI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (Poisons)
RN  - 0 (Sulfides)
RN  - 0 (Sulfur Compounds)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - *Biosensing Techniques
MH  - Environmental Monitoring
MH  - Humans
MH  - Poisons/*analysis
MH  - Sulfides/*analysis
MH  - Sulfur Compounds/*analysis
MH  - Water Pollutants, Chemical/*analysis
EDAT- 2009/07/04 09:00
MHDA- 2010/07/07 06:00
CRDT- 2009/07/04 09:00
PHST- 2009/07/04 09:00 [entrez]
PHST- 2009/07/04 09:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - 10.1021/ac9009353 [doi]
PST - ppublish
SO  - Anal Chem. 2009 Aug 1;81(15):6416-21. doi: 10.1021/ac9009353.