PMID- 19576081
OWN - NLM
STAT- MEDLINE
DCOM- 20091001
LR  - 20221207
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 48
IP  - 3
DP  - 2009 Mar
TI  - [A clinical study of chromosome translocations in extranodal marginal zone 
      lymphoma of mucosa-associated lymphoid tissue in Chinese patients].
PG  - 181-5
AB  - OBJECTIVE: To investigate the genetic aberrations in extranodal marginal zone 
      lymphoma of mucosa-associated lymphoid tissue (MALT) lymphomas from different 
      sites of the body in Chinese patients. METHODS: Two hundred and seventeen 
      paraffin-embedded MALT lymphoma specimens from 11 major sites were studied with 
      interphase fluorescence in situ hybridization (FISH) to detect t (11; 18) (q21; 
      q21)/API2-MALT1, t (1; 14) (p22; q32)/IGH-BCL10, (14; 18) (q32; q21)/IGH-MALT1 
      and BCL6 gene involved chromosome translocations. RESULTS: These translocations 
      were mutually exclusive and detected in 21% (46/217) of the cases, including t 
      (11; 18) (q21; q21) API2-MALT1 13% (29/217), t (1; 14) (p22; q32) IGH-BCL10 in 1% 
      (3/217), t (14; 18) (q32; q21) IGH-MALT1 1% (2/217), BCL6 involved translocation 
      in 2% (4/217) and IGH-unknown translocation partner in 4% (8/217). t (11; 18) 
      (q21; q21) API2-MALT1 was found with the highest frequency in MALT lymphoma from 
      lungs (47%, 8/17) and small intestine (29%, 4/14), followed by salivary gland 
      (17%, 1/6), stomach (14%, 12/84) and ocular adnexae (6%, 4/68). t (1; 14) (p22; 
      q32) was only detected in lungs (12%, 2/17) and stomach (1%, 1/84). t (14; 18) 
      (q32; q21) was mainly detected in lungs (6%, 1/17) and ocular adnexae (2%, 1/68). 
      BCL6 gene involved translocation was detected in salivary gland (17%, 1/6) and 
      stomach (4%, 3/84). CONCLUSIONS: It is demonstrated that the four translocations 
      occur with markedly variable frequencies in MALT lymphoma of different sites in 
      Chinese patients. The distributions of these chromosome translocations in Chinese 
      patients are slightly different from those reported in western patients.
FAU - Dong, Ge-Hong
AU  - Dong GH
AD  - Department of Pathology, Health Science Center, Peking University, Beijing 
      100191, China.
FAU - Wang, Gui-Qiu
AU  - Wang GQ
FAU - Gong, Li-Ping
AU  - Gong LP
FAU - Wang, Jin-Fen
AU  - Wang JF
FAU - Mo, Xiang-Lan
AU  - Mo XL
FAU - Liu, Hong-Gang
AU  - Liu HG
FAU - Dong, Li-Na
AU  - Dong LN
FAU - Zhou, Ying-Qiong
AU  - Zhou YQ
FAU - Zhang, Xue-Mei
AU  - Zhang XM
FAU - Feng, Zhen-Bo
AU  - Feng ZB
FAU - Gao, Zi-Fen
AU  - Gao ZF
FAU - Ye, Hong-Tao
AU  - Ye HT
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Child
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/epidemiology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
MH  - Young Adult
EDAT- 2009/07/07 09:00
MHDA- 2009/10/02 06:00
CRDT- 2009/07/07 09:00
PHST- 2009/07/07 09:00 [entrez]
PHST- 2009/07/07 09:00 [pubmed]
PHST- 2009/10/02 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2009 Mar;48(3):181-5.