PMID- 19576791
OWN - NLM
STAT- MEDLINE
DCOM- 20091112
LR  - 20220321
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 47
IP  - 2
DP  - 2009 Aug
TI  - Serum levels of monocyte chemoattractant protein-1 in periodontal health and 
      disease.
PG  - 77-81
LID - 10.1016/j.cyto.2009.05.012 [doi]
AB  - OBJECTIVES: Initial research has reported high levels of monocyte chemoattractant 
      protein-1 (MCP-1) in gingival crevicular fluid (GCF) of periodontitis patients. 
      Present study has been carried out to assess its concentration in serum and to 
      find its association with periodontal health and disease. DESIGN: 60 subjects 
      were divided into three groups (n=20) based on gingival index (GI), probing 
      pocket depth (PPD) and clinical attachment loss (CAL): healthy (group I), 
      gingivitis (group II) and chronic periodontitis (group III). A fourth group 
      (group IV) consisted of 20 subjects from group III, 6-8 weeks after treatment 
      [i.e. scaling and root planing (SRP)]. Serum samples obtained from each patient 
      were quantified for MCP-1 using enzyme-linked immunosorbent assay (ELISA). 
      RESULTS: The mean MCP-1 concentration in serum was found to be the highest in 
      group III i.e. 465.80 pg/ml and lowest in group I i.e. 155.20 pg/ml. For group II 
      (251.60 pg/ml) and group IV (263.20 pg/ml) the mean MCP-1 concentrations were 
      found to lie in between the concentrations obtained in group I and III. 
      CONCLUSIONS: Serum MCP-1 concentration was found to be, approximately one and 
      half folds higher in gingivitis patients (group II) and three folds higher in 
      chronic periodontitis patients (group III) as compared to healthy subjects (group 
      I). Further, the MCP-1 concentration increased proportionally with the severity 
      of disease in group II and III showing positive correlation with clinical 
      parameters. Thus, its role as an inflammatory biomarker in periodontal disease 
      can be proposed.
FAU - Pradeep, A R
AU  - Pradeep AR
AD  - Department of Periodontics, Government Dental College and Research Institute, 
      Fort, Bangalore, Karnataka, India. periodontics_gdc@rediffmail.com
FAU - Daisy, Happy
AU  - Daisy H
FAU - Hadge, Parag
AU  - Hadge P
LA  - eng
PT  - Journal Article
DEP - 20090702
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*blood
MH  - Chronic Periodontitis/blood/*immunology/therapy
MH  - Female
MH  - Gingivitis/blood/*immunology
MH  - Humans
MH  - Male
MH  - Periodontium/immunology
EDAT- 2009/07/07 09:00
MHDA- 2009/11/13 06:00
CRDT- 2009/07/07 09:00
PHST- 2009/01/27 00:00 [received]
PHST- 2009/04/01 00:00 [revised]
PHST- 2009/05/09 00:00 [accepted]
PHST- 2009/07/07 09:00 [entrez]
PHST- 2009/07/07 09:00 [pubmed]
PHST- 2009/11/13 06:00 [medline]
AID - S1043-4666(09)00139-2 [pii]
AID - 10.1016/j.cyto.2009.05.012 [doi]
PST - ppublish
SO  - Cytokine. 2009 Aug;47(2):77-81. doi: 10.1016/j.cyto.2009.05.012. Epub 2009 Jul 2.