PMID- 19577772
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20131121
IS  - 1095-8673 (Electronic)
IS  - 0022-4804 (Linking)
VI  - 161
IP  - 1
DP  - 2010 Jun 1
TI  - Effect of therapeutic pulsed ultrasound on lipoperoxidation and fibrogenesis in 
      an animal model of wound healing.
PG  - 168-71
LID - 10.1016/j.jss.2009.04.002 [doi]
AB  - Evidence from the literature has shown that the wound healing process is enhanced 
      by ultrasound therapy. In the present study, we measured thiobarbituric 
      acid-reactive substances (TBARS; index of lipoperoxidation) and hydroxyproline 
      (index of collagen synthesis) levels in wounds after therapeutic pulsed 
      ultrasound (TPU) treatment. Male Wistar rats were submitted to skin ulceration, 
      and three doses of TPU (0.4, 0.6, and 0.8W/cm(2)) were used. A circular area of 
      skin was removed with a punch biopsy from the medial dorsal region. After TPU for 
      10 days, TBARS (Draper and Hadley [21]) and hydroxyproline (Woessner [22]) levels 
      were measured in the tissue around the wound. Results showed that TPU improved 
      wound healing, since the wound size was significantly smaller 5 and 10 days after 
      ulceration in groups submitted to this treatment. Moreover, TBARS levels were 
      decreased in the 0.4, 0.6, and 0.8W/cm(2) TPU groups, and hydroxyproline levels 
      were increased in the 0.6 and 0.8W/cm(2) TPU groups. These findings indicate that 
      TPU presents beneficial effects on the wound healing process, probably by 
      speeding up the inflammatory phase and inducing collagen synthesis.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Freitas, Tiago P
AU  - Freitas TP
AD  - Laboratorio de Fisiopatologia Experimental, Programa de Pos-graduacao em Ciencias 
      da Saude, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil.
FAU - Gomes, Marcelo
AU  - Gomes M
FAU - Fraga, Daiane B
AU  - Fraga DB
FAU - Freitas, Luciana S
AU  - Freitas LS
FAU - Rezin, Gislaine T
AU  - Rezin GT
FAU - Santos, Patricia M
AU  - Santos PM
FAU - Silveira, Paulo C
AU  - Silveira PC
FAU - Paula, Marcos M
AU  - Paula MM
FAU - Pinho, Ricardo A
AU  - Pinho RA
FAU - Streck, Emilio L
AU  - Streck EL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090513
PL  - United States
TA  - J Surg Res
JT  - The Journal of surgical research
JID - 0376340
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 9007-34-5 (Collagen)
RN  - RMB44WO89X (Hydroxyproline)
SB  - IM
MH  - Animals
MH  - Collagen/biosynthesis
MH  - Fibrosis
MH  - Hydroxyproline/metabolism
MH  - *Lipid Peroxidation
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Skin/pathology
MH  - Skin Ulcer/metabolism/pathology
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - *Ultrasonic Therapy
MH  - *Wound Healing
EDAT- 2009/07/07 09:00
MHDA- 2010/05/21 06:00
CRDT- 2009/07/07 09:00
PHST- 2008/09/29 00:00 [received]
PHST- 2009/03/30 00:00 [revised]
PHST- 2009/04/01 00:00 [accepted]
PHST- 2009/07/07 09:00 [entrez]
PHST- 2009/07/07 09:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - S0022-4804(09)00193-0 [pii]
AID - 10.1016/j.jss.2009.04.002 [doi]
PST - ppublish
SO  - J Surg Res. 2010 Jun 1;161(1):168-71. doi: 10.1016/j.jss.2009.04.002. Epub 2009 
      May 13.