PMID- 19578770
OWN - NLM
STAT- MEDLINE
DCOM- 20090914
LR  - 20090706
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 22
IP  - 2
DP  - 2009 Aug
TI  - Chromosomal imbalances, 11q21 rearrangement and MECT1-MAML2 fusion transcript in 
      mucoepidermoid carcinomas of the salivary gland.
PG  - 305-11
AB  - The aim of this study was to determine genetic alterations in mucoepidermoid 
      carcinomas of the salivary gland in association with clinical and 
      histopathological parameters. Nineteen formalin-fixed, paraffin-embedded tumors 
      were analysed by using comparative genomic hybridization (CGH), fluorescence in 
      situ hybridization (FISH) on interphase nuclei and reverse 
      transcriptase-polymerase chain reaction (RT-PCR) for detection of MECT1-MAML2 
      fusion transcript. The CGH analysis showed an overrepresentation of chromosome X 
      and losses of entire chromosomes or regions on chromosome 1, 2, and 15 as the 
      most frequent copy number changes. In 37% of the analysed tumors a 
      MAML2-rearrangement by interphase FISH was detected, whereas 58% of the samples 
      showed expression of MECT1-MAML2 fusion transcript. We conclude that the presence 
      of MAML2-rearrangement as well as of MECT1-MAML2 fusion transcript may reflect a 
      more favourable prognosis and may be a useful marker for clinical prediction of 
      the biological behavior of these tumors as previously reported.
FAU - Verdorfer, Irmgard
AU  - Verdorfer I
AD  - Institute of Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria. 
      irmgard.verdorfer@i-med.ac.at
FAU - Fehr, Andre
AU  - Fehr A
FAU - Bullerdiek, Jorn
AU  - Bullerdiek J
FAU - Scholz, Nina
AU  - Scholz N
FAU - Brunner, Andrea
AU  - Brunner A
FAU - Krugmann, Jens
AU  - Krugmann J
FAU - Hager, Martina
AU  - Hager M
FAU - Haufe, Heike
AU  - Haufe H
FAU - Mikuz, Gregor
AU  - Mikuz G
FAU - Scholtz, Arne
AU  - Scholtz A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (MECT1-MAML2 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Mucoepidermoid/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/*genetics
MH  - RNA, Messenger/analysis
MH  - Salivary Gland Neoplasms/*genetics
EDAT- 2009/07/07 09:00
MHDA- 2009/09/15 06:00
CRDT- 2009/07/07 09:00
PHST- 2009/07/07 09:00 [entrez]
PHST- 2009/07/07 09:00 [pubmed]
PHST- 2009/09/15 06:00 [medline]
PST - ppublish
SO  - Oncol Rep. 2009 Aug;22(2):305-11.