PMID- 19579610
OWN - NLM
STAT- MEDLINE
DCOM- 20090827
LR  - 20131121
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 56
IP  - 90
DP  - 2009 Mar-Apr
TI  - COMT gene Val158Met polymorphism influences the severity of intestinal metaplasia 
      in H. pylori infected older subjects.
PG  - 411-5
AB  - BACKGROUND/AIMS: A complex interaction of host genetic and environmental factors 
      may be relevant in the development of Helocobacter pylori (H. pylori) related 
      gastroduodenal diseases. Catechol-O-methyltransferase (COMT) is expressed 
      catalyzes the methylation of various endobiotic and xenobiotic substances and 
      thus might protect DNA from oxidative damage. We aimed to clarify the effect of 
      COMT functional polymorphism on the severity of histological gastritis in a 
      Japanese population. METHODOLOGY: 203 subjects were included in this study. 
      Restriction fragment length polymorphism analysis was performed for polymorphisms 
      at codon 158 in the COMT gene. Gastritis scores of antral gastric mucosa were 
      assessed according to the updated Sydney system. RESULTS: COMT genotype 
      distribution in the study subjects was 158Val/Val (51.2%), 84Val/Met (41.4%), and 
      15Met/Met (7.4%). It was within the Hardy-Weinberg equilibrium (p = 0.73). In 
      over all subjects, the degree of intestinal metaplasia tended to be lower among 
      158Met/Met when compared to Val/Val (Val/Val vs. Met/Met; 0.59 +/- 0.93 vs. 0.13 
      +/- 0.52, p = 0.052). Among H. pylori infected subjects, the degree of intestinal 
      metaplasia was significantly lower among 158Met carriers in 50 years or older age 
      (Val/Val vs. Met carriers; 1.20 +/- 1.06 vs. 0.75 +/- 1.08, p = 0.0436). No 
      significant association was found between COMT genotypes and the degree of 
      gastritis in different gender CONCLUSION: Our data suggest that COMT gene 158Met 
      polymorphism is associate with a reduced risk of developing more severe 
      intestinal metaplasia in H. pylori infected older subjects.
FAU - Tahara, Tomomitsu
AU  - Tahara T
AD  - Department of Gastroenterology, Fujita Health University School of Medicine, 
      Japan. tomomiccyu@yahoo.co.jp
FAU - Shibata, Tomoyuki
AU  - Shibata T
FAU - Nakamura, Masakatsu
AU  - Nakamura M
FAU - Yoshioka, Daisuke
AU  - Yoshioka D
FAU - Okubo, Masaaki
AU  - Okubo M
FAU - Maruyama, Naoko
AU  - Maruyama N
FAU - Kamano, Toshiaki
AU  - Kamano T
FAU - Kamiya, Yoshio
AU  - Kamiya Y
FAU - Fujita, Hiroshi
AU  - Fujita H
FAU - Nagasaka, Mitsuo
AU  - Nagasaka M
FAU - Iwata, Masami
AU  - Iwata M
FAU - Takahama, Kazuya
AU  - Takahama K
FAU - Watanabe, Makoto
AU  - Watanabe M
FAU - Yamashita, Hiromi
AU  - Yamashita H
FAU - Nakano, Hiroshi
AU  - Nakano H
FAU - Hirata, Ichiro
AU  - Hirata I
FAU - Arisawa, Tomiyasu
AU  - Arisawa T
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Codon)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Age Factors
MH  - Catechol O-Methyltransferase/*genetics
MH  - Chi-Square Distribution
MH  - Codon
MH  - Female
MH  - Gastritis/genetics/pathology
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Helicobacter Infections/genetics
MH  - Helicobacter pylori
MH  - Humans
MH  - Intestines/*pathology
MH  - Japan
MH  - Male
MH  - Metaplasia/genetics
MH  - Middle Aged
MH  - Polymorphism, Genetic/genetics
MH  - Polymorphism, Restriction Fragment Length/*genetics
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Valine/*genetics
EDAT- 2009/07/08 09:00
MHDA- 2009/08/28 09:00
CRDT- 2009/07/08 09:00
PHST- 2009/07/08 09:00 [entrez]
PHST- 2009/07/08 09:00 [pubmed]
PHST- 2009/08/28 09:00 [medline]
PST - ppublish
SO  - Hepatogastroenterology. 2009 Mar-Apr;56(90):411-5.