PMID- 19579702
OWN - NLM
STAT- MEDLINE
DCOM- 20090728
LR  - 20131121
IS  - 1121-7138 (Print)
IS  - 1121-7138 (Linking)
VI  - 32
IP  - 2
DP  - 2009 Apr
TI  - Paradoxical immune reconstitution inflammatory syndrome associated with previous 
      Cryptococcus neoformans infection in an HIV-positive patient requiring 
      neurosurgical intervention.
PG  - 209-12
AB  - Immune reconstitution inflammatory syndrome (IRIS) in HIV-1-infected patients is 
      associated with an exaggerated inflammatory response against an opportunistic 
      infection during highly active antiretroviral therapy. The only review on IRIS 
      associated with Criptococcus neoformans reported 21 episodes including 
      lymphadenitis, necrotizing pneumonitis, breast and cutaneous abscess, and 
      cryptococcomas. To our knowledge this is the first report of IRIS associated with 
      previous meningeal criptococcal infection which required neurosurgical 
      intervention with placement of a ventriculo-peritoneal shunt to drain a CSF cyst 
      formed by exclusion of the temporal horn of the right lateral ventricle. We 
      demonstrate that this procedure is possible without complications such as 
      cryptococcal dissemination into the peritoneum.
FAU - Biagetti, Carlo
AU  - Biagetti C
AD  - Department of Digestive Apparatus Disease and Internal Medicine, Section of 
      Infectious Diseases, "Alma Mater Studiorum", University of Bologna, S. Orsola 
      Hospital, Bologna, Italy. biagetticarlo@libero.it
FAU - Nicola, Monica
AU  - Nicola M
FAU - Borderi, Marco
AU  - Borderi M
FAU - Pavoni, Michele
AU  - Pavoni M
FAU - Tampellini, Livia
AU  - Tampellini L
FAU - Verucchi, Gabriella
AU  - Verucchi G
FAU - Chiodo, Francesco
AU  - Chiodo F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Italy
TA  - New Microbiol
JT  - The new microbiologica
JID - 9516291
RN  - 0 (Antifungal Agents)
RN  - 8VZV102JFY (Fluconazole)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/cerebrospinal fluid/drug 
      therapy/*microbiology
MH  - Antifungal Agents/therapeutic use
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Brain/pathology
MH  - Cryptococcosis/*cerebrospinal fluid/drug therapy/microbiology
MH  - Cryptococcus neoformans/drug effects/metabolism
MH  - Female
MH  - Fluconazole/therapeutic use
MH  - HIV-1/drug effects
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically 
      induced/pathology/*surgery
MH  - Middle Aged
MH  - Ventriculoperitoneal Shunt
EDAT- 2009/07/08 09:00
MHDA- 2009/07/29 09:00
CRDT- 2009/07/08 09:00
PHST- 2009/07/08 09:00 [entrez]
PHST- 2009/07/08 09:00 [pubmed]
PHST- 2009/07/29 09:00 [medline]
PST - ppublish
SO  - New Microbiol. 2009 Apr;32(2):209-12.