PMID- 19580833
OWN - NLM
STAT- MEDLINE
DCOM- 20091211
LR  - 20201222
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 70
IP  - 10
DP  - 2009 Oct
TI  - Changes in activatory and inhibitory natural killer (NK) receptors may induce 
      progression to multiple myeloma: implications for tumor evasion of T and NK 
      cells.
PG  - 854-7
LID - 10.1016/j.humimm.2009.07.004 [doi]
AB  - The molecular basis of monoclonal gammopathy of undetermined significance (MGUS) 
      progression to a malignant monoclonal gammopathy remains poorly understood. It 
      was recently suggested that this process involves the suppression of innate and 
      adaptive immunity. In this study, we examined immunogenic differences in bone 
      marrow plasma cells among individuals without gammopathy (controls) and patients 
      with MGUS, multiple myeloma (MM), and plasma cell leukemia. We detected 
      differences in major histocompatibility complex (MHC) class I expression, MHC 
      class I chain-related molecule A, and CD95 that were more evident between MGUS 
      and MM samples; there appeared to be a critical imbalance between natural killer 
      (NK)-cell activating and inhibitory signals during the transition from MGUS to 
      MM. Our results indicate that the human leukocyte antigen (HLA) class I(bright), 
      MICA(dim/-), and CD95(dim/-) immunophenotype reported in myeloma cells may result 
      from an extensive interaction of malignant cells with cytotoxic T and NK cells 
      and appears to be immunoedited for the evasion of immunosurveillance.
FAU - Bernal, Monica
AU  - Bernal M
AD  - Servicio de Analisis Clinicos e Inmunologia, Hospital Universitario Virgen de las 
      Nieves, Granada, Spain.
FAU - Garrido, Pilar
AU  - Garrido P
FAU - Jimenez, Pilar
AU  - Jimenez P
FAU - Carretero, Rafael
AU  - Carretero R
FAU - Almagro, Manuel
AU  - Almagro M
FAU - Lopez, Pilar
AU  - Lopez P
FAU - Navarro, Pilar
AU  - Navarro P
FAU - Garrido, Federico
AU  - Garrido F
FAU - Ruiz-Cabello, Francisco
AU  - Ruiz-Cabello F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090704
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, KIR)
RN  - 0 (Receptors, Natural Cytotoxicity Triggering)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Cytotoxicity, Immunologic
MH  - Histocompatibility Antigens Class I/immunology/metabolism
MH  - Humans
MH  - Immunity, Active/immunology
MH  - Immunity, Innate/immunology
MH  - Immunophenotyping
MH  - Killer Cells, Natural/*immunology/metabolism
MH  - Multiple Myeloma/*immunology/metabolism
MH  - Paraproteinemias/immunology/metabolism
MH  - Receptors, KIR/*immunology/metabolism
MH  - Receptors, Natural Cytotoxicity Triggering/*immunology/metabolism
MH  - T-Lymphocytes, Cytotoxic/*immunology/metabolism
MH  - *Tumor Escape
MH  - fas Receptor/immunology/metabolism
EDAT- 2009/07/08 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/07/08 09:00
PHST- 2009/04/21 00:00 [received]
PHST- 2009/06/24 00:00 [revised]
PHST- 2009/07/01 00:00 [accepted]
PHST- 2009/07/08 09:00 [entrez]
PHST- 2009/07/08 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - S0198-8859(09)00170-0 [pii]
AID - 10.1016/j.humimm.2009.07.004 [doi]
PST - ppublish
SO  - Hum Immunol. 2009 Oct;70(10):854-7. doi: 10.1016/j.humimm.2009.07.004. Epub 2009 
      Jul 4.