PMID- 19581015
OWN - NLM
STAT- MEDLINE
DCOM- 20100108
LR  - 20111117
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 85
IP  - 3
DP  - 2009 Sep
TI  - The human leukocyte antigen class II gene has different contributions to 
      autoimmune type 1 diabetes with or without autoimmune thyroid disease in the 
      Japanese population.
PG  - 293-7
LID - 10.1016/j.diabres.2009.06.007 [doi]
AB  - AIM: Type 1 diabetes (T1D) is associated with autoimmune thyroid disease (AITD). 
      The human leukocyte antigen (HLA) has been extensively studied in these diseases. 
      We aimed to clarify the contribution of AITD on the susceptibility and resistance 
      of the HLA subtype to autoimmune T1D in the Japanese population. METHODS: The 
      frequency of the HLA DR-DQ haplotype was compared between 56 autoimmune T1D 
      patients with AITD and 71 autoimmune T1D patients without AITD, and control 
      subjects. RESULTS: The frequencies of DRB1 0405-DQB1 0401, DRB1 0802-DQB1 0302, 
      and DRB1 0901-DQB1 0303 haplotypes were significantly higher in T1D patients with 
      AITD than in control subjects. The frequencies of DRB1 0101-DQB1 0501, DRB1 
      0901-DQB1 0303, and DRB1 1302-DQB1 0604 haplotypes were significantly higher in 
      T1D patients without AITD than in control subjects. The frequencies of DRB1 
      1101-DQB1 0301 and DRB1 1501-DQB1 0602 haplotypes were significantly lower in T1D 
      patients with or without AITD than in control subjects. CONCLUSIONS: Our results 
      suggest that the susceptibility of the HLA subtype to autoimmune T1D differs 
      between T1D with AITD and T1D without AITD, whereas there is no difference 
      between the two groups with regard to HLA subtypes that confer protection against 
      autoimmune T1D.
FAU - Katahira, Masahito
AU  - Katahira M
AD  - Department of Endocrinology, Ichinomiya Municipal Hospital, 2-2-22 Bunkyo, 
      Ichinomiya, Aichi 491-8558, Japan. katahira-0034@umin.net
FAU - Maeda, Harumi
AU  - Maeda H
FAU - Tosaki, Takahiro
AU  - Tosaki T
FAU - Segawa, Satoko
AU  - Segawa S
LA  - eng
PT  - Journal Article
DEP - 20090705
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Diabetes Mellitus, Type 1/complications/genetics/*immunology
MH  - Female
MH  - *Genes, MHC Class II
MH  - Graves Disease/genetics/immunology
MH  - HLA-DQ Antigens/genetics/immunology
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics/immunology
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Thyroiditis, Autoimmune/classification/genetics/*immunology
MH  - Young Adult
EDAT- 2009/07/08 09:00
MHDA- 2010/01/09 06:00
CRDT- 2009/07/08 09:00
PHST- 2009/01/22 00:00 [received]
PHST- 2009/05/28 00:00 [revised]
PHST- 2009/06/08 00:00 [accepted]
PHST- 2009/07/08 09:00 [entrez]
PHST- 2009/07/08 09:00 [pubmed]
PHST- 2010/01/09 06:00 [medline]
AID - S0168-8227(09)00254-X [pii]
AID - 10.1016/j.diabres.2009.06.007 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2009 Sep;85(3):293-7. doi: 
      10.1016/j.diabres.2009.06.007. Epub 2009 Jul 5.