PMID- 19581665
OWN - NLM
STAT- MEDLINE
DCOM- 20091014
LR  - 20131121
IS  - 1872-9061 (Electronic)
IS  - 0300-2977 (Linking)
VI  - 67
IP  - 5
DP  - 2009 May
TI  - Hypomagnesaemia due to use of proton pump inhibitors--a review.
PG  - 169-72
AB  - Magnesium homeostasis is essential for many intracellular processes and depends 
      on the balance of intestinal absorption and renal excretion. Hypomagnesaemia may 
      arise from various disorders. We review the literature on hypomagnesaemia due to 
      the use of proton pump inhibitors, as illustrated by a case of a 76-year-old 
      woman with muscle cramps and lethargy caused by hypomagnesaemia and hypocalcaemia 
      with a low parathyroid hormone level while using esomeprazole, a proton pump 
      inhibitor (PPI). After oral magnesium repletion both abnormalities resolved. 
      Fractional magnesium excretion was low, excluding excessive renal loss. A causal 
      relation with PPI use was supported by the recurrence of hypomagnesaemia after 
      rechallenge. In the past decade our understanding of transcellular magnesium 
      transport was enhanced by the discovery of several gene mutations i.e. transient 
      receptor potential melastin (TR PM) 6 and 7. In this light we discuss the 
      possible aetiology of proton pump inhibitor related hypomagnesaemia.
FAU - Kuipers, M T
AU  - Kuipers MT
AD  - Department of Internal Medicine, Spaarne Hospital, Hoofddorp, the Netherlands.
FAU - Thang, H D
AU  - Thang HD
FAU - Arntzenius, A B
AU  - Arntzenius AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Neth J Med
JT  - The Netherlands journal of medicine
JID - 0356133
RN  - 0 (Antacids)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 3A3U0GI71G (Magnesium Oxide)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Aged
MH  - Antacids/administration & dosage
MH  - Anti-Ulcer Agents/*adverse effects
MH  - Esomeprazole/*adverse effects
MH  - Female
MH  - Humans
MH  - Hypocalcemia/*chemically induced/drug therapy
MH  - Magnesium Deficiency/*chemically induced/drug therapy/genetics
MH  - Magnesium Oxide/administration & dosage
MH  - Mutation/genetics
MH  - Proton Pump Inhibitors/*adverse effects
RF  - 11
EDAT- 2009/07/08 09:00
MHDA- 2009/10/15 06:00
CRDT- 2009/07/08 09:00
PHST- 2009/07/08 09:00 [entrez]
PHST- 2009/07/08 09:00 [pubmed]
PHST- 2009/10/15 06:00 [medline]
PST - ppublish
SO  - Neth J Med. 2009 May;67(5):169-72.