PMID- 19582456
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20211020
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 30
IP  - 5
DP  - 2010 Mar
TI  - The -383A>C TNFRI polymorphism is associated with soluble levels and clinical 
      activity in rheumatoid arthritis.
PG  - 655-9
LID - 10.1007/s00296-009-1049-6 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays a central role in inflammation, and 
      it has been directly implicated in the pathogenesis of rheumatoid arthritis (RA). 
      TNF-alpha activity is mediated through TNFRI and TNFRII cell surface receptors, 
      which act as physiological attenuators of TNF-alpha activity. We recruited 190 RA 
      patients and 190 healthy subjects (HS) in order to associate the -383A>C TNFRI 
      polymorphism with sTNFRI levels and DAS28 score in RA. In results, sTNFRI levels 
      were higher in RA patients than HS (P = 0.04). The -383A>C TNFRI polymorphism did 
      not show significant differences in both studied groups. However, in the RA group 
      the sTNFRI levels were significantly elevated (P = 0.004) in A/A genotype 
      carriers. In addition, the A/A genotype carriers had the higher DAS28 score than 
      A/C genotype (P = 0.02). These data suggest that -383A>C TNFRI polymorphism is 
      not a susceptibility marker in RA, whereas the increased levels of sTNFRI could 
      reflect the clinical activity in RA patients.
FAU - Valle, Y
AU  - Valle Y
AD  - Departamento de Biologia Molecular y Genomica, Centro Universitario de Ciencias 
      de la Salud, Instituto de Investigacion en Reumatologia y del Sistema Musculo 
      Esqueletico, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
FAU - Padilla-Gutierrez, J R
AU  - Padilla-Gutierrez JR
FAU - Torres-Carrillo, N M
AU  - Torres-Carrillo NM
FAU - Ledezma-Lozano, I Y
AU  - Ledezma-Lozano IY
FAU - Corona-Sanchez, E G
AU  - Corona-Sanchez EG
FAU - Vazquez-Del Mercado, M
AU  - Vazquez-Del Mercado M
FAU - Rangel-Villalobos, H
AU  - Rangel-Villalobos H
FAU - Gamez-Nava, J I
AU  - Gamez-Nava JI
FAU - Gonzalez-Lopez, L
AU  - Gonzalez-Lopez L
FAU - Munoz-Valle, Jose Francisco
AU  - Munoz-Valle JF
LA  - eng
PT  - Journal Article
DEP - 20090707
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (TNFRSF1A protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/diagnosis/ethnology/*genetics/immunology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Mexico/epidemiology
MH  - Middle Aged
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Receptors, Tumor Necrosis Factor, Type I/blood/*genetics
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
EDAT- 2009/07/08 09:00
MHDA- 2010/04/30 06:00
CRDT- 2009/07/08 09:00
PHST- 2009/06/01 00:00 [received]
PHST- 2009/06/21 00:00 [accepted]
PHST- 2009/07/08 09:00 [entrez]
PHST- 2009/07/08 09:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
AID - 10.1007/s00296-009-1049-6 [doi]
PST - ppublish
SO  - Rheumatol Int. 2010 Mar;30(5):655-9. doi: 10.1007/s00296-009-1049-6. Epub 2009 
      Jul 7.