PMID- 19584672
OWN - NLM
STAT- MEDLINE
DCOM- 20090723
LR  - 20220223
IS  - 1534-6080 (Electronic)
IS  - 0041-1337 (Linking)
VI  - 88
IP  - 1
DP  - 2009 Jul 15
TI  - Intravenous immunoglobulin a natural regulator of immunity and inflammation.
PG  - 1-6
LID - 10.1097/TP.0b013e3181a9e89a [doi]
AB  - Intravenous immunoglobulin (IVIG) products are derived from pooled human plasma 
      and have been used for the treatment of primary immunodeficiency disorders for 
      more than 25 years. IVIG products are also effective in the treatment of 
      autoimmune and inflammatory disorders; however, the precise mechanism(s) of 
      action is not known. Recent investigations suggest that IVIG has a much broader 
      ability to regulate cellular immunity including innate and adaptive components. 
      IVIG is also a recently recognized modifier of complement activation and injury. 
      Here, we discuss these important advancements and how this knowledge applies to 
      desensitization protocols and to the treatment of antibody-mediated rejection.
FAU - Jordan, Stanley C
AU  - Jordan SC
AD  - Department of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical 
      Center, Los Angeles, CA, USA. sjordan@cshs.org
FAU - Toyoda, Mieko
AU  - Toyoda M
FAU - Vo, Ashley A
AU  - Vo AA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunologic Factors)
SB  - IM
CIN - Am J Transplant. 2012 Oct;12(10):2567. PMID: 23009135
MH  - Animals
MH  - Complement Activation/drug effects
MH  - Desensitization, Immunologic/*methods
MH  - Graft Rejection/*drug therapy/immunology
MH  - Humans
MH  - Immunity, Cellular/drug effects
MH  - Immunity, Innate/drug effects
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Immunologic Factors/*therapeutic use
MH  - Inflammation/*drug therapy/immunology
MH  - Signal Transduction/drug effects
MH  - Transplantation Tolerance/drug effects
MH  - Transplantation, Homologous
RF  - 45
EDAT- 2009/07/09 09:00
MHDA- 2009/07/25 09:00
CRDT- 2009/07/09 09:00
PHST- 2009/07/09 09:00 [entrez]
PHST- 2009/07/09 09:00 [pubmed]
PHST- 2009/07/25 09:00 [medline]
AID - 00007890-200907150-00001 [pii]
AID - 10.1097/TP.0b013e3181a9e89a [doi]
PST - ppublish
SO  - Transplantation. 2009 Jul 15;88(1):1-6. doi: 10.1097/TP.0b013e3181a9e89a.