PMID- 1958472
OWN - NLM
STAT- MEDLINE
DCOM- 19920107
LR  - 20190704
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 79
IP  - 2
DP  - 1991 Oct
TI  - Human T-cell lymphotropic virus type I associated adult T-cell leukaemia/lymphoma 
      in Taiwan Chinese.
PG  - 156-61
AB  - Twenty-five Chinese patients with human T-cell lymphotropic virus type I (HTLV-I) 
      associated adult T-cell leukaemia/lymphoma (ATLL) were identified in Taiwan. No 
      patients had been outside Taiwan and none were descendants of Japanese heritage. 
      Their ages ranged from 28 to 71 years. There were 17 men and eight women. Main 
      clinical and laboratory features at presentation were lymphadenopathy (16), skin 
      lesions (11), hepatosplenomegaly (11), pulmonary lesions (11), hypercalcaemia 
      (10) and bone marrow infiltration (14). Peripheral blood was characterized by 
      leucocytosis with presence of pleomorphic abnormal lymphocytes but rare anaemia 
      or thrombocytopenia. The clinical subtypes were acute in 15, chronic in three, 
      smouldering in one, and lymphoma type in six. The immunophenotypes of the ATLL 
      cells were characterized by the expression of CD2+, CD4+, CD7-, CD8- and CD25+. 
      The overall prognosis was poor with a median survival of 5 months. The acute form 
      had a significantly shorter survival (2 months) than lymphoma type (13 months). 
      Susceptibility to various infections was common. Pulmonary complications 
      accounted for 73% of the causes of death. The clinicopathologic features of ATLL 
      in Taiwan are indistinguishable from those in HTLV-I endemic areas. The present 
      series adds to the knowledge of the worldwide pattern of the disease.
FAU - Shih, L Y
AU  - Shih LY
AD  - Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung Medical 
      College, Taipei, Taiwan, Republic of China.
FAU - Kuo, T T
AU  - Kuo TT
FAU - Dunn, P
AU  - Dunn P
FAU - Liaw, S J
AU  - Liaw SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow/pathology
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/ethnology/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - Taiwan
EDAT- 1991/10/01 00:00
MHDA- 1991/10/01 00:01
CRDT- 1991/10/01 00:00
PHST- 1991/10/01 00:00 [pubmed]
PHST- 1991/10/01 00:01 [medline]
PHST- 1991/10/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1991.tb04516.x [doi]
PST - ppublish
SO  - Br J Haematol. 1991 Oct;79(2):156-61. doi: 10.1111/j.1365-2141.1991.tb04516.x.