PMID- 19584738
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20100610
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Linking)
VI  - 22
IP  - 7
DP  - 2010 Jul
TI  - The response to hepatitis B vaccine: does it differ in celiac disease?
PG  - 787-93
LID - 10.1097/MEG.0b013e32832e9d41 [doi]
AB  - OBJECTIVES: There is a relationship between nonresponsiveness to hepatitis B 
      virus (HBV) vaccine and certain human leukocyte antigen (HLA) genotypes. In 
      healthy population, 4-10% vaccine recipients fail to produce protective levels of 
      antibodies to the HBV vaccine after standard immunization depending upon age and 
      the presence of various underlying diseases. Celiac disease (CD) is an 
      HLA-associated immunological disease. It has been suggested that certain HLA 
      haplotypes which are linked to CD are associated with nonresponse to HBV vaccine 
      as well. The aim of this study is to assess the response to HBV vaccine 
      prospectively in a group of CD and to explore the potential link between CD and 
      HBV vaccine nonresponse by studying shared HLA haplotypes. PATIENTS AND METHODS: 
      Sixty-three previously diagnosed celiac patients who were on a strict gluten-free 
      diet (GFD) and 54 healthy children were evaluated serologically for anti-HBs 
      status. Celiac children who were anti-HBs negative at baseline were fully 
      vaccinated prospectively, and reevaluated for the response to HBV vaccine. To 
      estimate the role of HLA type in HBV vaccine response in celiac patients, a 
      subgroup of both patients and control participants had HLA genotypes performed. 
      RESULTS: At enrollment, 27 (67.5%) children with CD and 48 (85.2%) healthy 
      children were anti-HBs positive, and the difference between patients and controls 
      was statistically significant (P<0.05). However, failure to respond to HBV 
      vaccine was only 3.6% (response rate 96.4%) in prospectively vaccinated celiac 
      patients. There was no relationship between HLA type and vaccine nonresponse in 
      our study group. CONCLUSION: The response to HBV vaccine in celiac children who 
      were compliant to GFD is not different from a healthy population. CD may be one 
      of the immune diseases associated with a high rate of HBV vaccine nonresponse but 
      it might not be permanent and treatment with GFD and compliance to the treatment 
      may ameliorate the immune response to HBV vaccine in celiac children.
FAU - Ertem, Deniz
AU  - Ertem D
AD  - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara 
      University Medical School, Istanbul, Turkey. denizertem@marmara.edu.tr
FAU - Gonen, Ismail
AU  - Gonen I
FAU - Tanidir, Cansaran
AU  - Tanidir C
FAU - Ugras, Meltem
AU  - Ugras M
FAU - Yildiz, Aysegul
AU  - Yildiz A
FAU - Pehlivanoglu, Ender
AU  - Pehlivanoglu E
FAU - Eksioglu-Demiralp, Emel
AU  - Eksioglu-Demiralp E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (HLA Antigens)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Adolescent
MH  - Celiac Disease/diet therapy/genetics/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Diet, Gluten-Free
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Hepatitis B/*prevention & control
MH  - Hepatitis B Antibodies/blood/immunology
MH  - Hepatitis B Vaccines/*immunology/therapeutic use
MH  - Hepatitis B virus/immunology
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Young Adult
EDAT- 2009/07/09 09:00
MHDA- 2010/09/21 06:00
CRDT- 2009/07/09 09:00
PHST- 2009/07/09 09:00 [entrez]
PHST- 2009/07/09 09:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
AID - 10.1097/MEG.0b013e32832e9d41 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2010 Jul;22(7):787-93. doi: 
      10.1097/MEG.0b013e32832e9d41.