PMID- 19585495
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20220309
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 125
IP  - 8
DP  - 2009 Oct 15
TI  - Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical 
      cancer in the Swedish population--a candidate gene approach.
PG  - 1851-8
LID - 10.1002/ijc.24529 [doi]
AB  - High-risk human papillomavirus (hrHPV) infection is the major risk factor for 
      cervical cancer (CxCa). The role of genetic susceptibility in the disease has 
      been suggested, but the existing data lack consistency. We conducted a nested 
      case-control study on 973 CxCa cases and 1,763 matched controls, from two Swedish 
      population-based cohorts to examine the association of common genetic variants 
      with CxCa risk. Human leukocyte antigen (HLA) alleles and 24 other polymorphisms 
      in 14 genes were selected on the basis of reported association or mechanistic 
      plausibility with an HPV infection or cervical cancer development. Genotyping was 
      conducted using multiplex PCR and Luminex technology. A significant association 
      of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds 
      ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the 
      LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 
      95% CI: 1.02-1.27), for those individuals carrying the rare allele. Additionally, 
      the alleles 0401 and 1501 of the HLA class II DRB1 locus were associated with an 
      increased risk (OR = 1.23, 95% CI: 1.04-1.45 and OR = 1.29, 95% CI: 1.11-1.50, 
      respectively), and allele 1301 was associated with decreased risk (OR = 0.59, 95% 
      CI: 0.47-0.73). The effects of CCND1 and the HLA*DRB1 alleles were independent of 
      the effect of smoking. We did not find any association of risk with polymorphisms 
      in genes related to the innate immune system. In conclusion, our study provides 
      evidence for genetic susceptibility to CxCa due to variations in genes involved 
      in the immune system and in cell cycle.
FAU - Castro, Felipe A
AU  - Castro FA
AD  - Division Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 
      D-69120 Heidelberg, Germany.
FAU - Haimila, Katri
AU  - Haimila K
FAU - Sareneva, Inna
AU  - Sareneva I
FAU - Schmitt, Markus
AU  - Schmitt M
FAU - Lorenzo, Justo
AU  - Lorenzo J
FAU - Kunkel, Nelli
AU  - Kunkel N
FAU - Kumar, Rajiv
AU  - Kumar R
FAU - Forsti, Asta
AU  - Forsti A
FAU - Kjellberg, Lennart
AU  - Kjellberg L
FAU - Hallmans, Goran
AU  - Hallmans G
FAU - Lehtinen, Matti
AU  - Lehtinen M
FAU - Hemminki, Kari
AU  - Hemminki K
FAU - Pawlita, Michael
AU  - Pawlita M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (CCND1 protein, human)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Interleukin-6)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Cervix Uteri/metabolism/pathology
MH  - Cyclin D1/*genetics
MH  - Female
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Interleukin-6/*genetics
MH  - Middle Aged
MH  - Papillomaviridae/genetics
MH  - Papillomavirus Infections/epidemiology/*genetics/virology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Risk Factors
MH  - Sweden/epidemiology
MH  - Uterine Cervical Neoplasms/epidemiology/*genetics/virology
MH  - Young Adult
EDAT- 2009/07/09 09:00
MHDA- 2009/09/22 06:00
CRDT- 2009/07/09 09:00
PHST- 2009/07/09 09:00 [entrez]
PHST- 2009/07/09 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - 10.1002/ijc.24529 [doi]
PST - ppublish
SO  - Int J Cancer. 2009 Oct 15;125(8):1851-8. doi: 10.1002/ijc.24529.